Skip to main content

ORIGINAL RESEARCH article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1416331
This article is part of the Research Topic Integrated Clinical Management and Neurorehabilitation for Lumbosacral Spinal Diseases View all 9 articles

Clinical characteristics and predisposing factors of lung metastasis in sacral chordoma: a cross-sectional cohort study of 221 cases

Provisionally accepted
Qianyu Shi Qianyu Shi *Wei Guo Wei Guo Siyue Yu Siyue Yu Jiuhui Xu Jiuhui Xu Tao Ji Tao Ji Xiaodong Tang Xiaodong Tang
  • Peking University People's Hospital, Beijing, China

The final, formatted version of the article will be published soon.

    Limited studies are available on the topic of lung metastasis in sacral chordoma. The primary objective of this study was to investigate the prevalence, characteristics, associated factors, and prognosis of lung metastasis in sacral chordoma. In this study, a total of 221 cases with primary sacral chordoma that underwent surgical resection at our center were included. Comprehensive demographic information, imaging findings, and oncological evaluations were collected and analyzed. The prevalence of lung metastasis in the cohort was 19.5%, with the lung emerging as the predominant site of distant metastasis. Recurrent chordoma cases exhibited a significantly higher lung metastasis rate in comparison to newly diagnosed chordoma cases (33.33% and 12.76%, p=0.0005). Patients with lung metastasis had a larger tumor size, a higher proportion of previous sacral chordoma surgeries and a greater likelihood of postoperative recurrence.Risk factors of lung metastasis were tumor size and postoperative recurrence.Radiotherapy was a protective factor of lung metastasis in the cohort. Patients with lung metastasis exhibited decreased median overall survival (91 vs. 144 months for those without lung metastasis, p<0.05) and recurrence-free survival (27 vs. 68 months, p<0.001) times. In summary, the current study elucidated the prevalence of lung metastasis in sacral chordoma in a large cohort, and our results underscore the importance of regular and long-term postoperative follow-ups of sacral chordoma patients.

    Keywords: Lung metastasis, Sacral chordoma, Risk factors, Survival, Recurrence

    Received: 23 Apr 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Shi, Guo, Yu, Xu, Ji and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qianyu Shi, Peking University People's Hospital, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.