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CASE REPORT article
Front. Oncol.
Sec. Pediatric Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1416083
This article is part of the Research Topic New Insights into Cancer Predisposition Syndromes in Pediatric Hematology-Oncology View all 6 articles
Paraneoplastic dermatomyositis and Hodgkin's lymphoma in a 14-year-old girl: a case report and literature review
Provisionally accepted- 1 Shandong Second Provincial General Hospital, Jinan, China
- 2 960th Hospital of the PLA, Jinan, Shandong Province, China
- 3 The 970th Hospital of Joint Logistics Support Force, Yantai, Shandong Province, China
Background: Juvenile dermatomyositis (JDM) is a rare autoimmune myopathy whose main clinical manifestations include a characteristic rash, symmetrical proximal muscle weakness, and elevated muscle enzymes. While approximately one-third of adult patients with dermatomyositis (DM) develop malignancies, typically within a year of diagnosis, this phenomenon is not commonly observed in patients with JDM. In this study, we present a rare case of both JDM and Hodgkin's lymphoma (HL) diagnosed in an adolescent female patient.Case description: A 14-year-old girl with proximal muscle weakness and myalgia for 8 weeks was admitted to the hospital and ultimately received a diagnosis of DM. A thorough physical examination revealed enlarged lymph nodes on both sides of the cervical, and a lymph node biopsy was performed to diagnose HL. After she underwent radiotherapy and chemotherapy, her symptoms of both HL and DM were alleviated.The phenomenon of JDM as a paraneoplastic syndrome associated with HL is very rare. Thus, routine cancer screening for DM in adolescents is currently not recommended. The diagnosis of JDM requires a detailed physical examination, and further tumor screening is necessary for patients with unusual physical findings, such as atypical rashes, enlarged lymph nodes, and enlargement of the spleen and/or liver.Even if no malignancy is detected when JDM is diagnosed, long-term follow-up is necessary.
Keywords: juvenile dermatomyositis, Hodgkin's lymphoma, Paraneoplastic syndrome, malignancy, Nodular sclerosing Hodgkin's lymphoma
Received: 11 Apr 2024; Accepted: 23 Jul 2024.
Copyright: © 2024 Ling, Hu, Xu, Feng, Li, Li, Cheng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Huai q. Hu, 960th Hospital of the PLA, Jinan, Shandong Province, China
Xiang y. Xu, Shandong Second Provincial General Hospital, Jinan, China
Jian l. Feng, Shandong Second Provincial General Hospital, Jinan, China
Ming z. Li, Shandong Second Provincial General Hospital, Jinan, China
Huan Li, The 970th Hospital of Joint Logistics Support Force, Yantai, Shandong Province, China
Ming Cheng, 960th Hospital of the PLA, Jinan, Shandong Province, China
Xiao l. Wang, 960th Hospital of the PLA, Jinan, Shandong Province, China
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