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REVIEW article

Front. Oncol.
Sec. Hematologic Malignancies
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1414102
This article is part of the Research Topic MDS: New Scientific and Clinical Developments View all 8 articles

The Immunoregulatory Role of Monocytes and Thrombomodulin in Myelodysplastic Neoplasms

Provisionally accepted
Luca Janssen Luca Janssen 1,2*Nathalie Van Leeuwen-Kerkhoff Nathalie Van Leeuwen-Kerkhoff 1,2Theresia Westers Theresia Westers 1,2Tanja D. De Gruijl Tanja D. De Gruijl 2,3,4Arjan Van De Loosdrecht Arjan Van De Loosdrecht 1,2*
  • 1 Department of Hematology Amsterdam UMC location VUmc, Amsterdam, Netherlands
  • 2 Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, Netherlands
  • 3 Department of Medical Oncology, VU Medical Center, Amsterdam, Netherlands
  • 4 Other, Amsterdam, Netherlands

The final, formatted version of the article will be published soon.

    Myelodysplastic neoplasms (MDS) are clonal disorders of the myeloid lineage leading to peripheral blood cytopenias. Dysregulation of innate immunity is hypothesized to be a potent driver of MDS. A recent study revealed increased thrombomodulin (TM) expression on classical monocytes in MDS, which was associated with prolonged survival. TM is a receptor with immunoregulatory capacities, however, its exact role in MDS development remains to be elucidated. In this review we focus on normal monocyte biology and report on the involvement of monocytes in myeloid disease entities with a special focus on MDS. Furthermore, we delve into the current knowledge on TM and its function in monocytes in health and disease and explore the role of TM-expressing monocytes as driver, supporter or epiphenomenon in the MDS bone marrow environment.

    Keywords: Monocytes, Thrombomodulin (TM), myelodysplastic neoplasms (MDS), Immune Regulation, Inflammation

    Received: 08 Apr 2024; Accepted: 12 Jul 2024.

    Copyright: © 2024 Janssen, Van Leeuwen-Kerkhoff, Westers, De Gruijl and Van De Loosdrecht. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Luca Janssen, Department of Hematology Amsterdam UMC location VUmc, Amsterdam, Netherlands
    Arjan Van De Loosdrecht, Department of Hematology Amsterdam UMC location VUmc, Amsterdam, Netherlands

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.