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REVIEW article

Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1413213
This article is part of the Research Topic Abnormal Angiogenesis in Tumors and the Improvement of Antiangiogenic Drugs View all articles

Targeted anti-angiogenesis therapy for advanced osteosarcoma

Provisionally accepted
Qiao Zhang Qiao Zhang 1*Yuxuan Xia Yuxuan Xia 2*Liyuan Wang Liyuan Wang 3*Yang Wang Yang Wang 4Yixi Bao Yixi Bao 2*Guo-sheng Zhao Guo-sheng Zhao 3*
  • 1 Department of Pain and Rehabilitation, Xinqiao Hospital, Shapingba, Chongqing, China
  • 2 Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • 3 Department of Spine Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • 4 Emergency Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    To date, despite extensive research, the prognosis of advanced osteosarcoma has not improved significantly. Thus, patients experience a reduced survival rate, suggesting that a reevaluation of current treatment strategies is required. Recently, in addition to routine surgery, chemotherapy and radiotherapy, researchers have explored more effective and safer treatments, including targeted therapy, immunotherapy, anti-angiogenesis therapy, metabolic targets therapy, and nanomedicine therapy. The tumorigenesis and development of osteosarcoma is closely related to angiogenesis. Thus, anti-angiogenesis therapy is crucial to treat osteosarcoma; however, recent clinical trials found that it has insufficient efficacy. To solve this problem, the causes of treatment failure and improve treatment strategies should be investigated. This review focuses on summarizing the pathophysiological mechanisms of angiogenesis in osteosarcoma and recent advances in anti-angiogenesis treatment of osteosarcoma.We also discuss some clinical studies, with the aim of providing new ideas to improve treatment strategies for osteosarcoma and the prognosis of patients.

    Keywords: Advanced osteosarcoma, Anti-angiogenesis therapy, mechanism of tumor angiogenesis, proangiogenic factors, Comprehensive therapy

    Received: 06 Apr 2024; Accepted: 08 Aug 2024.

    Copyright: © 2024 Zhang, Xia, Wang, Wang, Bao and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qiao Zhang, Department of Pain and Rehabilitation, Xinqiao Hospital, Shapingba, 400037, Chongqing, China
    Yuxuan Xia, Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Liyuan Wang, Department of Spine Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Yixi Bao, Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Guo-sheng Zhao, Department of Spine Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.