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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Surgical Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1413041
Postoperative fever after elective minimally invasive resection for gastric and colorectal cancer: incidence, risk factors and characteristics
Provisionally accepted
Fan He
1*
Chenglin Tang
1*
Fuyu Yang
1*
Dongqin Zhao
1*
Junjie Xiong
1*
Yu Zou
1*
De-Fei Chen
1
Guoquan Huang
2*
Kun Qian
1*- 1 First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- 2 Hubei Provincial Key Lab of Selenium Resources and Bioapplications, Enshi, China, Enshi, China
Purpose: To analyse the incidence and risk factors of postoperative fever (POF) in gastrointestinal cancer (GIC), discuss the influence of POF on short-term clinical outcomes, and predict anastomotic leakage (AL) based on POF characteristics. Methods: Overall, 1362 patients that underwent radical resection for GIC were retrospectively analyzed. POF was defined as a postoperative temperature ≥38℃ during hospitalisation. Patients were divided according to whether they experienced POF. The influence of POF on short-term clinical outcomes was analysed using propensity score matching. A subgroup analysis was conducted to examine the relationship between different POF characteristics and AL or infection-related complications.Results: POF occurred in 172 patients (12.6%). Overall, 115 patients (66.9%) had fever ≥38.6℃, while 105 (61.0%) had fever at postoperative day (POD) 2, and 73 (42.4%) had POF multiple times.Multivariate analysis showed that patients with a preoperative albumin level < 37 g/L (odds ratio[OR]=1.57, p=0.016), operative time >195min (OR=1.55, p=0.020), and radical gastrectomy (OR=1.84, p=0.009) were more likely to develop POF. Compared to patients without fever, drainage tube indwelling time, duration of antibiotic use, and hospital stay were prolonged, while AL and infection-related complications were more common in patients with POF. POF ≥38.6℃ (OR=1.74, p=0.039) and PCT >0.7 ng/mL (OR=2.
Keywords: postoperative fever, gastrointestinal cancer, Anastomotic leakage, multivariate analysis, Retrospective Studies
Received: 06 Apr 2024; Accepted: 19 Dec 2024.
Copyright: © 2024 He, Tang, Yang, Zhao, Xiong, Zou, Chen, Huang and Qian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fan He, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Chenglin Tang, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Fuyu Yang, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Dongqin Zhao, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Junjie Xiong, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Yu Zou, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Guoquan Huang, Hubei Provincial Key Lab of Selenium Resources and Bioapplications, Enshi, China, Enshi, China
Kun Qian, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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