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CASE REPORT article

Front. Oncol.
Sec. Hematologic Malignancies
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1412021

A Case of Effective Treatment of Primary Myelofibrosis with Nodular Panniculitis Using Ruxolitinib Combined with Corticosteroids

Provisionally accepted
Guzailinuer Wufuer Guzailinuer Wufuer 1Jia-lin Zhao Jia-lin Zhao 1*Qin Huang Qin Huang 1*Ainiwaer Babayi Ainiwaer Babayi 1*Dilinuer Abudureyimu Dilinuer Abudureyimu 1*Min Mao Min Mao 1*Ming-hui Duan Ming-hui Duan 2*
  • 1 People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, China
  • 2 Peking Union Medical College Hospital (CAMS), Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    We report the case of a 54-year-old healthy Han Chinese male presenting with fever, pallor, erythematous subcutaneous nodules on the limbs, and significant anemia as indicated by routine blood tests, with no response to antimicrobial therapy. Initial skin biopsy was inconclusive. The erythematous subcutaneous nodules on the limbs rapidly progressed to widespread subcutaneous nodules across the body, with worsening anemia. Bone marrow biopsy revealed multifocal fibroblastic proliferation with focal fibrosis, classified as MF-2, and positive for the JAK2V617F mutation alongside SRSF2 positivity. Whole-body PET-CT scans did not reveal any lymph nodes or suspect lesions with high SUV uptake. A subsequent skin biopsy identified the condition as nodular panniculitis (NP), leading to a final diagnosis of primary myelofibrosis ( PMF ) with NP. The patient initially received treatment with oral ruxolitinib and prednisone acetate, resulting in normalization of body temperature, resolution of erythematous nodules, and normalization of blood parameters.

    Keywords: subcutaneous nodule, Primary Myelofibrosis, Nodular panniculitis, Ruxolitinib, Prednisone acetate

    Received: 04 Apr 2024; Accepted: 31 Jul 2024.

    Copyright: © 2024 Wufuer, Zhao, Huang, Babayi, Abudureyimu, Mao and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jia-lin Zhao, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, China
    Qin Huang, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, China
    Ainiwaer Babayi, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, China
    Dilinuer Abudureyimu, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, China
    Min Mao, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, China
    Ming-hui Duan, Peking Union Medical College Hospital (CAMS), Beijing, 100730, Beijing Municipality, China

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