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CLINICAL TRIAL article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1411353
This article is part of the Research Topic Surgical Management of Colorectal Pathologies View all 8 articles
Effect of prehabilitation exercises on postoperative frailty in patients undergoing laparoscopic colorectal cancer surgery
Provisionally accepted- 1 First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- 2 Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Wuhan University, Enshi, Hubei, China
Background: To improve perioperative frailty status in patients undergoing laparoscopic colorectal cancer surgery (LCCS), we explored a new intensive prehabilitation program that combines prehabilitation exercises with standard enhanced recovery after surgery (ERAS) and explored its impact.We conducted a prospective randomized controlled trial. Between April 2021 to August 2021, patients undergoing elective LCCS were randomized into the standardized ERAS (S-ERAS) group or ERAS based on prehabilitation (group PR-ERAS). Patients in the PR-ERAS group undergoing prehabilitation exercises in the perioperative period in addition to standard enhanced recovery after surgery. We explored the effects of this prehabilitation protocol on frailty, short-term quality of recovery (QoR), psychological status, postoperative functional capacity, postoperative outcomes, and pain.Results: In total, 125 patients were evaluated, and 95 eligible patients were enrolled and randomly allocated to the S-ERAS (n = 45) and PR-ERAS (n = 50) groups. The Fried score was higher in the PR-ERAS group on postoperative day (7 (2(2,3) vs. 3(2,4), P = 0.012). The QoR-9 was higher in the PR-ERAS group than in the S-ERAS group on the 1st, 2nd, 3rd, and 7th postoperative days. The PR-ERAS group had an earlier time to first ambulation (P < 0.050) and time to first flatus (P < 0.050).Prehabilitation exercises can improve postoperative frailty and accelerate recovery in patients undergoing LCCS but may not improve surgical safety. Therefore, better and more targeted prehabilitation recovery protocols should be explored.
Keywords: Frailty, Laparoscopic colorectal cancer surgery, colorectal cancer, Enhanced recovery after surgery, Prehabilitation exercises
Received: 02 Apr 2024; Accepted: 26 Aug 2024.
Copyright: © 2024 Yang, Yuan, Liu, Tang, He, Chen, Xiong, Huang and Qian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fuyu Yang, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Ye Yuan, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Wenwen Liu, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Chenglin Tang, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Fan He, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Junjie Xiong, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Guoquan Huang, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Wuhan University, Enshi, 445000, Hubei, China
Kun Qian, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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