AUTHOR=Han Ruyue , Yang Jing , Zhu Yingying , Gan Runliang 

TITLE=Wnt signaling in gastric cancer: current progress and future prospects

JOURNAL=Frontiers in Oncology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1410513

DOI=10.3389/fonc.2024.1410513

ISSN=2234-943X

ABSTRACT=<p>Levels of the Wnt pathway components are abnormally altered in gastric cancer cells, leading to malignant cell proliferation, invasion and metastasis, poor prognosis and chemoresistance. Therefore, it is important to understand the mechanism of Wnt signaling pathway in gastric cancer. We systematically reviewed the molecular mechanisms of the Wnt pathway in gastric cancer development; and summarize the progression and the challenges of research on molecular agents of the Wnt pathway.</p>