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CASE REPORT article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1410291
This article is part of the Research Topic Management of Rare Oncological Cases View all 40 articles

Urachal Adenocarcinoma with Cervical Invasion Misdiagnosed as Primary Cervical Adenocarcinoma: A Case Report and Literature Review

Provisionally accepted
Yiran Wang Yiran Wang 1,2Maomao Li Maomao Li 1,2Kaixuan Yang Kaixuan Yang 3Qingli Li Qingli Li 1,2*Ping Wang Ping Wang 1,2*
  • 1 Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, chengdu, China
  • 2 Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 3 Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu, China

The final, formatted version of the article will be published soon.

    Background: Urachal carcinoma (UrC) is a rare malignancy with no known specific early symptoms. It is often diagnosed at advanced stages and is associated with poor prognosis. Case presentation: This study presents a rare case of urachal adenocarcinoma (UrAC) invading the bladder and vagina in a female patient. Initially, the patient was misdiagnosed as having a primary cervical adenocarcinoma 2.5 years prior. Subsequently, anterior pelvic exenteration and bilateral ureterocutaneostomies were performed. Twenty months after the first surgery, the patient was diagnosed with rectal metastasis and received gemcitabine chemotherapy. After achieving a stable disease state, the patient underwent laparoscopic ultralow rectal anterior resection, ultralow anastomosis of the sigmoid colon and rectum, prophylactic transverse colostomy, and right common iliac and external iliac lymph node dissection. The patient then received a cycle of postoperative chemotherapy with oxaliplatin and capecitabine; however, treatment was stopped due to adverse reactions. The patient continues to receive regular follow-ups, and her general condition is good. Conclusions: UrC is rare, and preoperative differential diagnosis is difficult. This is the first report of UrC being misdiagnosed as cervical cancer. The presented case highlights the importance of accurate histopathological examination and comprehensive analysis. Anterior pelvic exenteration was also identified as a potentially effective treatment strategy for patients with local pelvic recurrence of UrC, although further investigation is required.

    Keywords: Urachal carcinoma, cervical cancer, Histopathological examination, anterior pelvic exenteration, case report

    Received: 31 Mar 2024; Accepted: 06 Sep 2024.

    Copyright: © 2024 Wang, Li, Yang, Li and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qingli Li, Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, chengdu, China
    Ping Wang, Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, chengdu, China

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