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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1410229

Comparison of 68 Ga-PSMA PET and mpMRI for Prostate Cancer Local Staging: A Comprehensive Review and Direct Meta-Analysis

Provisionally accepted
Xinyu Jin Xinyu Jin 1Yijie Cai Yijie Cai 1Xiaolu Ren Xiaolu Ren 2*
  • 1 Shanxi Medical University, Taiyuan, Shanxi Province, China
  • 2 General Hospital of Ningxia Medical University, Yinchuan, China

The final, formatted version of the article will be published soon.

    Purpose: This meta-analysis is conducted to evaluate the comparative diagnostic efficacy of 68 Ga-PSMA PET vs. mpMRI in detecting local staging of prostate cancer(PCa).A comprehensive search was conducted in the PubMed and Embase databases to identify publications up to February 2024. The analysis included studies that evaluated the direct comparison of 68 Ga-PSMA PET and mpMRI for local staging of prostate cancer. The reliability of the analyzed studies was evaluated using the QUADAS-2 tool.The meta-analysis included 10 articles involving 505 patients, which revealed that both 68 Ga-PSMA PET and mpMRI had similar sensitivities and specificities in detecting extracapsular extension(ECE) and seminal vesicle invasion(SVI). The sensitivities for ECE were 0.56 (95% CI: 0.41-0.71) for 68 Ga-PSMA PET and 0.57 (95% CI: 0.43-0.71) for mpMRI, and specificities were both 0.84 ( 68 Ga-PSMA PET 95% CI: 0.75-0.91, mpMRI 95% CI: 0.76-0.91).For SVI, sensitivities were 0.57 (95% CI: 0.46-0.68) for 68 Ga-PSMA PET and 0.70 (95% CI: 0.60-0.80) for mpMRI, with specificities of 0.92 (95% CI: 0.86-0.96) for 68 Ga-PSMA PET and 0.94 (95% CI: 0.89-0.98) for mpMRI. There were no notable variations in sensitivity or specificity between the two methods for detecting ECE and SVI (P = 0.89 and 0.93 for ECE, 0.09 and 0.57 for SVI).Conclusions: This meta-analysis indicates that 68 Ga-PSMA PET has similar sensitivity and specificity to mpMRI in local prostate cancer staging. Nevertheless, the limited study sample size calls for further, larger prospective studies to validate these findings.

    Keywords: XJ: Data curation, Formal analysis, methodology, Software, Writing -original draft. YC: Data curation, visualization, Writing -original draft. XR: Data curation, Writing -review & editing 68 Ga-PSMA PET

    Received: 28 May 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Jin, Cai and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaolu Ren, General Hospital of Ningxia Medical University, Yinchuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.