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REVIEW article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1409519
This article is part of the Research Topic Advances in Brain Tumor Therapy View all 3 articles

Research Progress on the Role of PTEN Deletion or Mutation in the Immune Microenvironment of Glioblastoma

Provisionally accepted
Leiya Du Leiya Du *Qian Zhang Qian Zhang *Yi Li Yi Li *Ting Li Ting Li *Qingshan Deng Qingshan Deng Yuming Jia Yuming Jia *Kaijian Lei Kaijian Lei *Daohong Kan Daohong Kan *Fang Xie Fang Xie *Shenglan Huang Shenglan Huang *
  • Second People’s Hospital of Yibin, Yibin, China

The final, formatted version of the article will be published soon.

    Recent advances in immunotherapy represent a breakthrough in solid tumor treatment but the existing data indicate that immunotherapy is not effective in improving the survival time of patients with glioblastoma. The tumor microenvironment (TME) exerts a series of inhibitory effects on immune effector cells, which limits the clinical application of immunotherapy. Growing evidence shows that phosphate and tension homology deleted on chromsome ten (PTEN) plays an essential role in TME immunosuppression of glioblastoma. Emerging evidence also indicates that targeting PTEN can improve the anti-tumor immunity in TME and enhance the immunotherapy effect, highlighting the potential of PTEN as a promising therapeutic target. This review summarizes the function and specific upstream and downstream targets of PTEN-associated immune cells in glioblastoma TME, providing potential drug targets and therapeutic options for glioblastoma.

    Keywords: Glioblastoma, Pten, Immunity, Tumor Microenvironment, immunosuppressive

    Received: 30 Mar 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Du, Zhang, Li, Li, Deng, Jia, Lei, Kan, Xie and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Leiya Du, Second People’s Hospital of Yibin, Yibin, 644000, China
    Qian Zhang, Second People’s Hospital of Yibin, Yibin, 644000, China
    Yi Li, Second People’s Hospital of Yibin, Yibin, 644000, China
    Ting Li, Second People’s Hospital of Yibin, Yibin, 644000, China
    Yuming Jia, Second People’s Hospital of Yibin, Yibin, 644000, China
    Kaijian Lei, Second People’s Hospital of Yibin, Yibin, 644000, China
    Daohong Kan, Second People’s Hospital of Yibin, Yibin, 644000, China
    Fang Xie, Second People’s Hospital of Yibin, Yibin, 644000, China
    Shenglan Huang, Second People’s Hospital of Yibin, Yibin, 644000, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.