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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Head and Neck Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1406975
This article is part of the Research Topic Approaches to Illustrate the Tumor Immune Microenvironment View all 4 articles

Immunomodulatory role of tumor microenvironment on oncological outcomes in advanced laryngeal cancer

Provisionally accepted
Anna Rzepakowska Anna Rzepakowska *Joanna Olędzka Joanna Olędzka Piotr Daniel Piotr Daniel Marta Mękarska Marta Mękarska Michał Żurek Michał Żurek Karol 3 Kulbaka Karol 3 Kulbaka Łukasz Fus Łukasz Fus
  • Medical University of Warsaw, Warsaw, Poland

The final, formatted version of the article will be published soon.

    Background: The study evaluated the prognostic impact of immune microenvironment in LSCC with markers of major immune cells to identify the key determinants of short-term disease-free survival (ST DFS) and reveal factors related to disease progression. Methods: Study cohort included 61 patients after total laryngectomy; male (83.6%); 64.3 years median age at the time of surgery. 25 patients had long term DFS (over 5 years), 8moderate DFS (between 2-5 years), and 28 short term DFS (less than 2 years). Immunohistochemistry staining and evaluation was performed in postlaryngectomy samples.Results: The samples' assessment revealed that the mean expression of all analyzed markers was the highest both in stroma and tumor compartment for short term DFS (ST DFS) patients. Analysis confirmed that high stromal density of CD8 cells (p=0.038) significantly correlated with DFS, and that the increased presence of CD57 cells (p=0.021) was significantly associated with ST DFS. Moreover, the high density of CD68 cells in the tumor epithelial compartment had negative prognostic impact on DFS (p=0.032). Analysis of the overall survival in the studied cohort with Kaplan-Meyer curves founds stromal high density of CD68 cells to be a significant negative predictor of OS (p=0.008).The observed association of CD68 cells infiltrates with progression and prognosis in LSCC provides potential screening and therapeutical opportunities for patients with unfavorable course of the disease.

    Keywords: cancer-related inflammation, Immune markers, tumor infiltrating lymphocytes, tumor associated macrophages, tumor stroma, Laryngeal cancer, Tumor Microenvironment

    Received: 25 Mar 2024; Accepted: 22 Oct 2024.

    Copyright: © 2024 Rzepakowska, Olędzka, Daniel, Mękarska, Żurek, Kulbaka and Fus. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Anna Rzepakowska, Medical University of Warsaw, Warsaw, Poland

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.