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CASE REPORT article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1405755
This article is part of the Research Topic Surgical Management of Spine and Spinal Cord Metastasis View all 6 articles

Combination of triple chemotherapy and sequential re-irradiation as salvage for recurrent treatment-refractory hemangiopericytoma of extraspinal dura: A case report

Provisionally accepted
Min Wang Min Wang 1Wanrui Lv Wanrui Lv 2Xi Chen Xi Chen 1Ke Cheng Ke Cheng 3*
  • 1 West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 2 Meishan People's Hospital, Meishan, China
  • 3 Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, China

The final, formatted version of the article will be published soon.

    Introduction: Hemangiopericytoma (HPC) in the central nervous system (CNS) is rare. Our report aims to present an HPC case with multiple surgeries at the lumbar spine, and demonstrates an effective treatment as salvage.Case report: In this report, we present the case of a young girl with recurrent meningeal invasion of lumbar spinal HPC. The patient underwent multiple surgeries to remove the tumors, and adjuvant radiotherapy was administered after the initial resection. And it presented a pathological anaplastic transformation with subsequent accelerated recurrence. A combination therapy approach involving triple chemotherapy and sequential re-irradiation was found to be effective as salvage treatment at the third recurrence.Surgical resection remains the primary treatment modality for HPC in the spine, despite its high tendency for local recurrence and the risk of metastasis. For unresectable recurrent HPC, combining chemotherapy and sequential re-irradiation might be a highly effective, and safe reference regimen as the salvage treatment for the refractory case.

    Keywords: Hemangiopericytoma, Solitary fibrous tumor, Re-irradiation, triple chemotherapy, HPC

    Received: 23 Mar 2024; Accepted: 30 Oct 2024.

    Copyright: © 2024 Wang, Lv, Chen and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ke Cheng, Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, China

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