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REVIEW article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1405727
This article is part of the Research Topic Regulation of Immune Subsets in Tumor Microenvironment View all articles
Molecular characteristics and immune microenvironment of gastrointestinal stromal tumours: targets for therapeutic strategies
Provisionally accepted- 1 The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
- 2 Guangzhou Kingmed Diagnostics Group Co., Ltd., Guangzhou, China
- 3 Department of Endocrinology, The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China
- 4 Department of Thyroid and Breast Surgery, Baiyun Hospital, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours, arising mainly from the interstitial cells of Cajal (ICCs) of the gastrointestinal tract. As radiotherapy and chemotherapy are generally ineffective for GISTs, the current primary treatment is surgical resection. However, surgical resection is not choice for most patients. Therefore, new therapeutic strategies are urgently needed. Targeted therapy, represented by tyrosine kinase inhibitors (TKIs), and immunotherapy, represented by immune checkpoint inhibitor therapies and chimeric antigen receptor T-cell immunotherapy (CAR-T), offer new therapeutic options in GISTs and have shown promising treatment responses. In this review, we summarize the molecular classification and immune microenvironment of GISTs and discuss the corresponding targeted therapy and immunotherapy options. This updated knowledge may provide more options for future therapeutic strategies and applications in GISTs.
Keywords: Gastrointestinal Stromal Tumours, Immunotherapy, targeted therapy, Molecular Characteristics, immune microenvironment
Received: 23 Mar 2024; Accepted: 24 Jun 2024.
Copyright: © 2024 Yu, Yu, luo, zhang, zeng, chen, lin, chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Wang, Department of Endocrinology, The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China
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