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REVIEW article

Front. Oncol.
Sec. Cancer Epidemiology and Prevention
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1405267
This article is part of the Research Topic Accelerating Cancer Genomics Research in Sub-Saharan Africa View all articles

Emerging Biomarkers for Non-Invasive Diagnosis and Treatment of Cancer: A Systematic Review

Provisionally accepted
Suleiman Zakari Suleiman Zakari 1,2*Nguedia K. Niels Nguedia K. Niels 1Grace V. Olagunju Grace V. Olagunju 3Precious C. Nnaji Precious C. Nnaji 1Oluwabusayo Ogunniyi Oluwabusayo Ogunniyi 1Mercy Tebamifor Mercy Tebamifor 1Emmanuel N. Israel Emmanuel N. Israel 1Sunday E. Atawodi Sunday E. Atawodi 4Olubanke Ogunlana Olubanke Ogunlana 1
  • 1 Covenant University, Ota, Nigeria
  • 2 Federal University of Health Sciences Otukpo, Otukpo, Benue, Nigeria
  • 3 New Mexico State University, Las Cruces, New Mexico, United States
  • 4 Federal University Lokoja, Lokoja, Nigeria

The final, formatted version of the article will be published soon.

    Cancer remains a global health challenge, necessitating continuous advancements in diagnostic and treatment strategies. This review focuses on the utility of non-invasive biomarkers in cancer diagnosis and treatment, their role in early detection, disease monitoring, and personalized therapeutic interventions. Through a systematic review of the literature, we identified 45 relevant studies that highlight the potential of these biomarkers across various cancer types, such as breast, prostate, lung, and colorectal cancers. The non-invasive biomarkers discussed include liquid biopsies, epigenetic markers, non-coding RNAs, exosomal cargo, and metabolites. Notably, liquid biopsies, particularly those based on circulating tumor tumour DNA (ctDNA), have emerged as the most promising method for early, non-invasive cancer detection due to their ability to provide comprehensive genetic and epigenetic information from easily accessible blood samples. This review demonstrates how noninvasive biomarkers can facilitate early cancer detection, accurate subtyping, and tailored treatment strategies, thereby improving patient outcomes. It underscores the transformative potential of noninvasive biomarkers in oncology, highlighting their application for enhancing early detection, survival rates, and treatment precision in cancer care.

    Keywords: biomarkers, cancer diagnosis, Non-invasive biomarker, cancer treatment Articles reporting outcomes related to biomarker sensitivity, specificity, or clinical utility. v Original research articles, Systematic reviews, and meta-analyses. Study Selection

    Received: 22 Mar 2024; Accepted: 05 Jul 2024.

    Copyright: © 2024 Zakari, Niels, Olagunju, Nnaji, Ogunniyi, Tebamifor, Israel, Atawodi and Ogunlana. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Suleiman Zakari, Covenant University, Ota, Nigeria

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.