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REVIEW article

Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1404025
This article is part of the Research Topic Regulation of Immune Subsets in Tumor Microenvironment View all 4 articles

Tumor microenvironment: recent advances in immunotherapies of pancreatic cancer

Provisionally accepted
Sharon V. Thankachan Sharon V. Thankachan 1Vijayalakshmi Jayaraman Vijayalakshmi Jayaraman 1Liza Datta Liza Datta 1Soniga Apthi Soniga Apthi 1Binish F. Zaman Binish F. Zaman 1Raghav Gurunathan Raghav Gurunathan 1Anuppama Suresh Anuppama Suresh 1Parthasarathy Chandrakesan Parthasarathy Chandrakesan 2KANAGARAJ PALANIYANDI KANAGARAJ PALANIYANDI 1*DHANAVATHY Gnanasampanthapandian DHANAVATHY Gnanasampanthapandian 1,3*
  • 1 Department of Biotechnology, SRM Institute of Science and Technology, Kancheepuram, Tamil Nadu, India
  • 2 University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
  • 3 SRM Institute of Science and Technology, Chennai, India

The final, formatted version of the article will be published soon.

    The immune system plays a critical decisive role in the progression of pancreatic cancer. Pancreatic cancer cancer is the third leading cause of cancer-related mortality in the United States. The lethality of pancreatic cancer is determined by its immune immunologic advantage, which is managed byachieved by an immunosuppressive microenvironment, low mutational burden, and poor low T-cell invasion. While Although immunotherapies (e.g., checkpoint blockade or genetically engineered T cells) still do not seem appear to show viabilitybe viable, there is increasing accumulating evidences displayed suggests that suggest impertinent combinations of conventional therapies and different various procedures lead to immunotherapy in pancreatic cancer. This review focuses on the significance importance of the tumor microenvironment and the promising roles of immunotherapies in pancreatic cancer.

    Keywords: Immunotherapy, Tumor Microenvironment, T cells, B cells, Cytokines, Immunosuppression

    Received: 04 Apr 2024; Accepted: 30 Aug 2024.

    Copyright: © 2024 Thankachan, Jayaraman, Datta, Apthi, Zaman, Gurunathan, Suresh, Chandrakesan, PALANIYANDI and Gnanasampanthapandian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    KANAGARAJ PALANIYANDI, Department of Biotechnology, SRM Institute of Science and Technology, Kancheepuram, Tamil Nadu, India
    DHANAVATHY Gnanasampanthapandian, SRM Institute of Science and Technology, Chennai, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.