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REVIEW article
Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1404025
This article is part of the Research Topic Regulation of Immune Subsets in Tumor Microenvironment View all 4 articles
Tumor microenvironment: recent advances in immunotherapies of pancreatic cancer
Provisionally accepted- 1 Department of Biotechnology, SRM Institute of Science and Technology, Kancheepuram, Tamil Nadu, India
- 2 University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
- 3 SRM Institute of Science and Technology, Chennai, India
The immune system plays a critical decisive role in the progression of pancreatic cancer. Pancreatic cancer cancer is the third leading cause of cancer-related mortality in the United States. The lethality of pancreatic cancer is determined by its immune immunologic advantage, which is managed byachieved by an immunosuppressive microenvironment, low mutational burden, and poor low T-cell invasion. While Although immunotherapies (e.g., checkpoint blockade or genetically engineered T cells) still do not seem appear to show viabilitybe viable, there is increasing accumulating evidences displayed suggests that suggest impertinent combinations of conventional therapies and different various procedures lead to immunotherapy in pancreatic cancer. This review focuses on the significance importance of the tumor microenvironment and the promising roles of immunotherapies in pancreatic cancer.
Keywords: Immunotherapy, Tumor Microenvironment, T cells, B cells, Cytokines, Immunosuppression
Received: 04 Apr 2024; Accepted: 30 Aug 2024.
Copyright: © 2024 Thankachan, Jayaraman, Datta, Apthi, Zaman, Gurunathan, Suresh, Chandrakesan, PALANIYANDI and Gnanasampanthapandian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
KANAGARAJ PALANIYANDI, Department of Biotechnology, SRM Institute of Science and Technology, Kancheepuram, Tamil Nadu, India
DHANAVATHY Gnanasampanthapandian, SRM Institute of Science and Technology, Chennai, India
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