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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1403822

Impact of Osteopenia and Osteosarcopenia on the Outcomes after Surgery of Hepatobiliary-pancreatic Cancers

Provisionally accepted
HongYan Jin HongYan Jin 1*Xiaofeng Wang Xiaofeng Wang 1Min Wu Min Wu 2Qian Liu Qian Liu 1Wei He Wei He 1Yong Tian Yong Tian 1Yan Zhang Yan Zhang 1Cuiping Li Cuiping Li 1Yanni Liu Yanni Liu 1Anqi Yu Anqi Yu 1
  • 1 Wuhan Puren Hospital, Wuhan, China
  • 2 Third People's Hospital of Honghe Prefecture, Gejiu, Yunnan, China

The final, formatted version of the article will be published soon.

    The purpose of this study is to investigate potential associations between osteopenia, osteosarcopenia, and postoperative outcomes in patients with hepatobiliary-pancreatic cancer (HBPC). Methods: Three online databases, including Embase, PubMed, and the Cochrane Library, were thoroughly searched for literature describing the relationship between osteopenia, osteosarcopenia, and outcomes of surgical treatment of HBPC patients from the start of each database to September 29, 2023. The Newcastle-Ottawa Scale was used to rate the quality of the studies. Results:This analysis included a total of 16 articles with a combined patient cohort of 2,599 individuals. The results demonstrated that HBPC patients with osteopenia had significantly inferior OS (HR: 2.27, 95% CI: 1.70-3.03, p < 0.001) and RFS (HR: 1.96, 95% CI: 1.42-2.71, p < 0.001) compared to those without osteopenia. Subgroup analysis demonstrated that these findings were consistent across univariate and multivariate analyses, as well as hepatocellular carcinoma, biliary tract cancer, and pancreatic cancer. The risk of postoperative major complications was significantly higher in patients with osteopenia compared to those without osteopenia (OR: 1.66, 95% CI: 1.19-2.33, p < 0.001). Besides, we also found that the presence of osteosarcopenia in HBPC patients was significantly related to poorer OS (HR: 3.31, 95% CI: 2.00-5.48, p < 0.001) and PFS (HR: 2.50, 95% CI: 1.62-3.84, p < 0.001) in comparison to those without osteosarcopenia. Conclusion: Preoperative osteopenia and osteosarcopenia can predict poorer OS and RFS with HBPC after surgery.

    Keywords: osteopenia, osteosarcopenia, Pancreatic Cancer, Biliary Tract Neoplasms, Hepatocellular Carcinoma ( HCC)

    Received: 20 Mar 2024; Accepted: 04 Jul 2024.

    Copyright: © 2024 Jin, Wang, Wu, Liu, He, Tian, Zhang, Li, Liu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: HongYan Jin, Wuhan Puren Hospital, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.