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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1403666

Clinical value of the modified Naples prognostic score in patients with stage II-III colon cancer undergoing curative resection: a retrospective study from the real world

Provisionally accepted
Xiaopeng Li Xiaopeng Li 1Chen Cheng Chen Cheng 2Xiongwei Huo Xiongwei Huo 1Chenye Zhao Chenye Zhao 1Hang Yuan Hang Yuan 1Gang Chen Gang Chen 1Junhui Yu Junhui Yu 1Mingchao Mu Mingchao Mu 1Xuejun Sun Xuejun Sun 1*
  • 1 The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
  • 2 Shaanxi Provincial Cancer Hospital, Xi'an, Shaanxi Province, China

The final, formatted version of the article will be published soon.

    The Naples prognostic score (NPS) based on nutritional and inflammatory status is attracting growing attention for predicting postoperative outcomes in various cancers.This study aimed to assess the prognostic significance of a modified NPS (M-NPS) and establish and validate nomograms incorporating M-NPS in stage II-III colon cancer patients who underwent curative resection.We retrospectively analyzed 328 stage II-III colon cancer patients who underwent curative resection at our hospital from January 2011 to December 2016. Kaplan-Meier (KM) survival analysis and Cox proportional hazard regression analysis were executed for overall survival (OS) and cancer-specific survival (CSS). Independent prognostic factors were applied to construct nomograms of OS and CSS. The performance of the nomograms was evaluated by the concordance index (C-index), the area under the receiver operating characteristic (ROC) curve (AUC), calibration curves, and decision curve analysis (DCA).Of a total of 328 cases, 153 cases were in group 0, 145 in group 1, and 30 in group 2.Significant OS or CSS differences were observed between group 0 and group 1, and between group 0 and group 2. Age, obstruction, gross tumor type, N stage, and M-NPS group were independent prognostic factors for OS, while obstruction, gross tumor type, N stage, and M-NPS group were independent prognostic indicators for CSS. In addition, 328 patients were randomly divided into the training set and the validation set.Nomograms were constructed for the prediction of OS and CSS. In the training and validation cohort, the C-index and ROC analysis showed good discrimination, calibration curves indicated excellent agreement between nomogram-predicted survival and actual survival outcomes, and DCA curves demonstrated good predictive performance.M-NPS was a reliable survival predictor in patients with stage II-III colon cancer undergoing curative resection. Nomograms incorporating M-NPS for OS and CSS had good predictive performance and clinical utility.

    Keywords: Keyword colon cancer, modified Naples prognostic score, prognostic factors, Curative resection, nomogram

    Received: 03 Apr 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Li, Cheng, Huo, Zhao, Yuan, Chen, Yu, Mu and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xuejun Sun, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China

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