AUTHOR=Luo Yingzhe , Cai Xuebin , Yang Biao , Lu Facheng , Yi Cheng , Wu Guoyu TITLE=Advances in understanding the role of immune checkpoint LAG-3 in tumor immunity: a comprehensive review JOURNAL=Frontiers in Oncology VOLUME=14 YEAR=2024 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1402837 DOI=10.3389/fonc.2024.1402837 ISSN=2234-943X ABSTRACT=

Lymphocyte activation gene 3 (LAG-3), also known as CD223, is an emerging immune checkpoint that follows PD-1 and CTLA-4. Several LAG-3 targeting inhibitors in clinical trials and the combination of relatlimab (anti-LAG-3) and nivolumab (anti-PD-1) have been approved for treating - unresectable or metastatic melanoma. Despite the encouraging clinical potential of LAG-3, the physiological function and mechanism of action in tumors are still not well understood. In this review, we systematically summarized the structure of LAG-3, ligands of LAG-3, cell-specific functions and signaling of LAG-3, and the current status of LAG-3 inhibitors under development.