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CASE REPORT article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1402819

An intracranial yolk sac tumor with initial symptom of hemorrhage in the basal ganglia: Case Report

Provisionally accepted
Qiang Liu Qiang Liu 1*Xuecui Du Xuecui Du 2*Yunyan Wang Yunyan Wang 1*Ruihua Hou Ruihua Hou 3Yuqing Chen Yuqing Chen 4*Teng Chen Teng Chen 1*
  • 1 Qilu Hospital, Shandong University, Jinan, Shandong Province, China
  • 2 The Third People's Hospital of Tai’an City, TaiAn, China
  • 3 University of Southampton, Southampton, Hampshire, United Kingdom
  • 4 School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom

The final, formatted version of the article will be published soon.

    We report a case and follow-up of an adult male with intracranial yolk sac tumor (YST). Initially, the patient presented with abnormal high signals in the right basal ganglia on MRI, misdiagnosed as a cavernous hemangioma. However, within two years, the condition rapidly progressed into a large, hypervascular solid neoplasm, leading to a basal ganglia hemorrhage. Comprehensive evaluation of clinical symptoms, imaging, surgical findings, serology, histopathology, and genetic analysis confirmed the diagnosis of a yolk sac tumor. The patient underwent prompt surgical resection, followed by radiotherapy and chemotherapy. Six months post-treatment, his condition remains stable, with no recurrence. Notably, early MRI revealed Wallerian degeneration in the brainstem, suggesting that benign-appearing basal ganglia lesions may sometimes result from malignant infiltration by germ cell tumors or other cancers. To prevent misdiagnosis and ensure timely treatment, a stereotactic biopsy is recommended. We hope this case provides a valuable reference for diagnosing and treating YSTs and contributes to ongoing research aimed at improving patient survival.

    Keywords: yolk sac tumor, Intracranial germ-cell tumor, Wallerian Degeneration, hemorrhage in the basal ganglia, YST Font: (Default) DengXian, (Asian) DengXian His stiff-neck, Kernig, Brudzinski signs and in his serum

    Received: 18 Mar 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Liu, Du, Wang, Hou, Chen and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qiang Liu, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China
    Xuecui Du, The Third People's Hospital of Tai’an City, TaiAn, China
    Yunyan Wang, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China
    Yuqing Chen, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
    Teng Chen, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China

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