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CASE REPORT article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1402550
This article is part of the Research Topic Exploring the Potential for Advancements in Spinal Neurosurgery: Revolutionizing Treatment Pathways and Improving Quality of Life View all 15 articles

Denosumab combined with microwave ablation excisional scraping for giant cell tumor of the thoracic spine: A case report and literature review

Provisionally accepted
Zukang Miao Zukang Miao 1Zhiwei Han Zhiwei Han 2Kai Zheng Kai Zheng 1Ming Xu Ming Xu 1Xue Yu Xue Yu 3Changsheng Han Changsheng Han 1Xiuchun Yu Xiuchun Yu 1*
  • 1 960th Hospital of the PLA, Jinan, Shandong Province, China
  • 2 Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China
  • 3 Shandong Second Medical University, Weifang, China

The final, formatted version of the article will be published soon.

    Denosumab has recently become an important part of the treatment regime for spinal giant cell tumors of the bone (GCTB). Its use has significantly reduced the risk of surgery and postoperative complications in patients with spinal GCTB. However, the use of denosumab has not yet been optimized to reap the maximum benefits. Here, we have reported the case of a patient who was treated with denosumab in combination with excision and scraping for GCTB of the T10 vertebrae, which achieved good tumor control and no recurrence at the 2-year postoperative follow-up. We have also reviewed the case in the light of relevant literature as well as presented our ideas and recommendations for the optimal use of denosumab.

    Keywords: Denosumab, excisional scraping, Giant Cell Tumor of Bone, case report, literature review

    Received: 17 Mar 2024; Accepted: 29 Aug 2024.

    Copyright: © 2024 Miao, Han, Zheng, Xu, Yu, Han and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiuchun Yu, 960th Hospital of the PLA, Jinan, Shandong Province, China

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