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REVIEW article

Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1402350

Alternative splicing regulation and its therapeutic potential in bladder cancer

Provisionally accepted
Lina Li Lina Li 1*Ting Jin Ting Jin 2Liang Hu Liang Hu 3Ding Jin Ding Jin 2*
  • 1 School of Medicine, Jinhua Polytechnic, Jinhua, China
  • 2 Department of Gastroenterology, Jinhua Central Hospital, Jinhua, Zhejiang Province, China
  • 3 Department of Urology, Jinhua Central Hospital, Jinhua, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Bladder cancer is one of the leading causes of mortality globally. The development of bladder cancer is closely associated with alternative splicing, which regulates human gene expression and enhances the diversity of functional proteins. Alternative splicing is a distinctive feature of bladder cancer, and as such, it may hold promise as a therapeutic target. This review aims to comprehensively discuss the current knowledge of alternative splicing in the context of bladder cancer. We review the process of alternative splicing and its regulation in bladder cancer. Moreover, we emphasize the significance of abnormal alternative splicing and splicing factor irregularities during bladder cancer progression. Finally, we explore the impact of alternative splicing on bladder cancer drug resistance and the potential of alternative splicing as a therapeutic target.

    Keywords: Alternative Splicing, splicing factor irregularity, aberrant splicing events, Bladder cancer, cancer therapy

    Received: 17 Mar 2024; Accepted: 05 Jul 2024.

    Copyright: © 2024 Li, Jin, Hu and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lina Li, School of Medicine, Jinhua Polytechnic, Jinhua, China
    Ding Jin, Department of Gastroenterology, Jinhua Central Hospital, Jinhua, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.