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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Skin Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1399486

Hotspots and future trends of dermatofibrosarcoma protuberans

Provisionally accepted
Zhen Meng Zhen Meng 1,2Rui Zhang Rui Zhang 1Zhihong Sun Zhihong Sun 2Cong Fu Cong Fu 2Zhiyu Li Zhiyu Li 1Luying Wang Luying Wang 2Ran Huo Ran Huo 1,2Feng Xue Feng Xue 2*
  • 1 Shandong University, Jinan, Shandong Province, China
  • 2 Shandong Provincial Hospital, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    Objective. Dermatofibrosarcoma protuberans (DFSP) is a moderately malignant soft tissue sarcoma with localized infiltrative growth. The extensive surgical scope and high recurrence rate of DFSP brings dysfunctional, aesthetic, psychological and economic problems to patients. The aim of this study is to explore the global publication characteristics, research hotspots and future trends of DFSP over the past 32 years via an intuitive visualized way. Methods. The Web of Science Core Collection (WoSCC) database was searched for papers related to DFSP published from 1990 to 2022. Then bibliometric analysis of these publications was performed, including collaborative networks, co-citation analysis of journals and references, and cluster analysis of keywords. Results. A total of 1588 papers were retrieved between 1990-2022. The United States was the most prolific country, followed by China. The article Imatinib Mesylate in Advanced Dermatofibrosarcoma Protuberans: Pooled Analysis of Two Phase II Clinical Trials , received most citations. Research hotspots and future trends are mainly focused on disease diagnosis, COL1A1-PDGFB fusion gene, drug and surgical treatment, fibrosarcomatous transformation, and immunotherapy. Conclusion. The research on DFSP faces several clinical challenges. This study provides novel insights into future research directions and scientific decisions for DFSP.

    Keywords: Dermatofibrosarcoma protuberans, Fibrosarcomatous transformation, bibliometric analysis, fusion gene, Tumor Microenvironment, Immunotherapy

    Received: 12 Mar 2024; Accepted: 15 Oct 2024.

    Copyright: © 2024 Meng, Zhang, Sun, Fu, Li, Wang, Huo and Xue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Feng Xue, Shandong Provincial Hospital, Jinan, 250021, Shandong Province, China

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