Qian Chen
Kai Zheng
Ming Xu
chun x. Yu
*The final, formatted version of the article will be published soon.
CASE REPORT article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1399021
This article is part of the Research Topic Multimodality Therapy for Older Cancer Patients View all 9 articles
Denosumab combined with chemotherapy followed by anlotinib in the treatment of multiple metastases of malignant peripheral nerve sheath tumor: A case report and literature review
Provisionally accepted- The 960th Hospital of the People’s Liberation Army, Jinan, China
Primary intraosseous malignant peripheral nerve sheath tumors (MPNSTs) are rare yet highly aggressive neoplasms originating from peripheral nerves.Typically manifesting as soft tissue masses accompanied by pain or functional impairment, these tumors pose significant challenges in management. Surgical intervention remains the cornerstone of treatment for patients with MPNST lacking distant metastasis, with generally modest success rates. In cases of recurrence and metastasis, the pursuit of effective systemic therapies has been a focus of clinical investigation. Herein, we present a case study involving an elderly female patient with refractory MPNST. In light of surgical limitations, a multimodal therapeutic approach combining chemotherapy, denosumab, and subsequent administration of anlotinib was pursued following collaborative consultation. This regimen yielded noteworthy clinical benefits, exemplifying a promising avenue in the management of challenging MPNST cases.
Keywords: Malignant peripheral nerve sheath tumor, Anlotinib, Denosumab, Adjuvant chemotherapy, case report
Received: 11 Mar 2024; Accepted: 10 Jul 2024.
Copyright: © 2024 Chen, Zheng, Xu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
chun x. Yu, The 960th Hospital of the People’s Liberation Army, Jinan, China
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