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REVIEW article

Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1395284

Progress of fluorescence imaging in lymph node dissection surgery for prostate and bladder cancer

Provisionally accepted
Mingquan Xu Mingquan Xu 1,2*Panpan Li Panpan Li 3Jinzheng Wei Jinzheng Wei 4Pengyu Yan Pengyu Yan 1Yunmeng Zhang Yunmeng Zhang 1Xinyu Guo Xinyu Guo 1Chao Liu Chao Liu 1Xiaofeng Yang Xiaofeng Yang 1,2
  • 1 Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China
  • 2 Shanxi Medical University, Taiyuan, Shanxi Province, China
  • 3 Department of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China
  • 4 Department of Orthopedics, First Hospital of Shanxi Medical University, Taiyuan, China

The final, formatted version of the article will be published soon.

    Fluorescence imaging is a relatively new imaging method used to visualize different tissue structures to help guide intraoperative operations, which has potential advantages with high sensitivity and contrast compared to conventional imaging. In this work, we review fluorescent contrast agents and devices used for lymphatic system imaging. Indocyanine green is the most widely utilized due to its high sensitivity, specificity, low background fluorescence, and safety profile. In prostate and bladder cancer lymph node dissection, the complex lymphatic drainage can result in missed metastatic nodes and extensive dissection increases the risk of complications like lymphocele, presenting a significant challenge for urologists. Fluorescence-guided sentinel lymph node dissection facilitates precise tumor staging. The combination of fluorescence and radiographic imaging improves the accuracy of lymph node staging. Multimodal imaging presents new potential for precisely identifying metastatic pelvic lymph nodes.

    Keywords: Fluorescence Imaging, Fluorescent contrast agent, Pelvic lymph node dissection, lymph node metastasis, Multimodal Imaging

    Received: 05 Mar 2024; Accepted: 13 Sep 2024.

    Copyright: © 2024 Xu, Li, Wei, Yan, Zhang, Guo, Liu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mingquan Xu, Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.