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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Epidemiology and Prevention
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1393132
REVISING CANCER INCIDENCE IN A CENTRAL EUROPEAN COUNTRY: A HUNGARIAN NATIONWIDE STUDY BETWEEN 2011-2019 BASED ON A HEALTH INSURANCE FUND DATABASE
Provisionally accepted- 1 MSD Pharma Hungary Ltd., Budapest, Hungary
- 2 University of Pécs II. Internal Medicine Clinic and Nephrology Center no, Pécs, Hungary
- 3 National Institute of Oncology and National Tumor Biology Laboratory, Budapest, Hungary
- 4 Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
- 5 Department of Oncology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary
- 6 Department of Molecular Immunology and Toxicology, National Institute of Oncology, Budapest, Hungary
- 7 Department of Anatomy and Histology, University of Veterinary Medicine Budapest, Budapest, Hungary
- 8 Chemistry Institute, University of Debrecen, Debrecen, Hungary
- 9 RxTarget Ltd, Szolnok, Hungary
- 10 University of Veterinary Medicine Budapest, Budapest, Hungary
- 11 Department of Deputy Chief Medical Officer II., National Public Health Center, Budapest, Hungary
- 12 Institute of Digital Health Sciences, Semmelweis University, Budapest, Hungary
- 13 Syntesia Medical Communications Ltd., Budapest, Hungary
- 14 Hungarian National Cancer Registry and National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary
- 15 Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary
- 16 National Korányi Institute of Pulmonology, Budapest, Hungary
- 17 1st Department of Pulmonology, National Korányi Institute of Pulmonology, Budapest, Hungary
- 18 Department of Pulmonology, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary
- 19 Pulmonology Hospital Törökbálint, Department of Pulmonology, Törökbálint, Hungary
- 20 Department of Pulmonology, Semmelweis University, Budapest, Hungary
- 21 Faculty of Medicine, Department of Obstetrics and Gynecology, University of Debrecen, Debrecen, Hungary
- 22 Fejér County Szent György, University Teaching Hospital, Székesfehérvár, Hungary
- 23 Department of Oncotherapy, University of Szeged, Szeged, Hungary
- 24 Hungarian Central Statistical Office, Department of Population Statistics, Budapest, Hungary
- 25 Center for Health Technology Assessment, Semmelweis University, Budapest, Hungary
- 26 Syreon Research Institute, Budapest, Hungary
Background The nationwide HUN-CONCORD study examined cancer incidence and mortality rates in Hungary from 2011 to 2019. Methods Using data from the National Health Insurance Fund (NHIF) and Central Statistical Office (CSO), our retrospective study analyzed newly diagnosed malignancies between Jan 1, 2011, and Dec 31, 2019. Age-standardized incidence and mortality rates were calculated for all and for different tumor types using both the 1976 and 2013 European Standard Populations (ESP). Findings The number of newly diagnosed cancer cases decreased from 60,554 to 56,675 between 2011–2019. Age-standardized incidence rates were much lower in 2018, than previously estimated (475.5 vs. 580.5/100,000 person-years [PYs] in males and 383.6 vs. 438.5/100,000 PYs in females; ESP 1976). All-site cancer incidence showed a mean annual decrease of 1.9% (95% CI: 2.4%-1.4%) in men and 1.0% (95% CI:1.42%-0.66%) in women, parallel to mortality trends (-1.6% in males and -0.6% in females; ESP 2013). In 2018, the highest age-standardized incidence rates were found for lung (88.3), colorectal (82.2), and prostate cancer (62.3) in men, and breast (104.6), lung (47.7), and colorectal cancer (45.8) in women. The most significant decreases in incidence rates were observed for stomach (4.7%), laryngeal (4.4%), and gallbladder cancers (3.5%), with parallel decreases in mortality rates (3.9%, 2.7% and 3.2%, respectively). Interpretation We found a lower incidence of newly diagnosed cancer cases for Hungary compared to previous estimates, and decreasing trends in cancer incidence and mortality, in line with global findings and the declining prevalence of smoking.
Keywords: Cancer burden, Cancer Incidence, Cancer mortality, financial health insurance database, real-wold data, Hungary
Received: 28 Feb 2024; Accepted: 27 Aug 2024.
Copyright: © 2024 Kiss, Szabó, Polgár, Horváth, Nagy, Fábián, Kovács, Surján, Barcza, Kenessey, Wéber, Wittmann, Molnár, Gyöngyösi, Benedek, Karamousouli, Abonyi-Tóth, Bertókné Tamás, Fürtös, Bogos, Moldvay, Gálffy, Tamási, Müller, Krasznai, Ostoros, Pápai-Székely, Maráz, Branyiczkiné Géczy, Hilbert, Berki, Rokszin and Vokó. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zoltán Kiss, MSD Pharma Hungary Ltd., Budapest, Hungary
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