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REVIEW article

Front. Oncol.
Sec. Cancer Genetics
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1389468

Application and research progress of single cell sequencing technology in leukemia

Provisionally accepted
Dan Xie Dan Xie 1Bangquan An Bangquan An 2*MingYue Yang MingYue Yang 1*Lei Wang Lei Wang 1*Min Guo Min Guo 1*Heng Luo Heng Luo 3*Shengwen Huang Shengwen Huang 2*Fa Sun Fa Sun 1*
  • 1 Guizhou University, Guiyang, Guizhou Province, China
  • 2 Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China
  • 3 Guizhou Medical University, Guiyang, Guizhou Province, China

The final, formatted version of the article will be published soon.

    Leukemia is a malignant tumor with high heterogeneity and a complex evolutionary process. It is difficult to resolve the heterogeneity and clonal evolution of leukemia cells by applying traditional bulk sequencing techniques, thus preventing a deep understanding of the mechanisms of leukemia development and the identification of potential therapeutic targets.However, with the development and application of single-cell sequencing technology, it it now possible to investigate the gene expression profile, mutations, and epigenetic features of leukemia at the single-cell level, thus providing a new perspective for leukemia research. In this article, we review the recent applications and advances of single-cell sequencing technology in leukemia research, discuss its potential for enhancing our understanding of the mechanisms of leukemia development, discovering therapeutic targets and personalized treatment, and provide reference guidelines for the significance of this technology in clinical research.

    Keywords: Leukemia, single-cell sequencing, Acute Myeloid Leukemia, heterogeneity, Leukemia cells

    Received: 21 Feb 2024; Accepted: 08 Aug 2024.

    Copyright: © 2024 Xie, An, Yang, Wang, Guo, Luo, Huang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bangquan An, Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China
    MingYue Yang, Guizhou University, Guiyang, 550025, Guizhou Province, China
    Lei Wang, Guizhou University, Guiyang, 550025, Guizhou Province, China
    Min Guo, Guizhou University, Guiyang, 550025, Guizhou Province, China
    Heng Luo, Guizhou Medical University, Guiyang, 550025, Guizhou Province, China
    Shengwen Huang, Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China
    Fa Sun, Guizhou University, Guiyang, 550025, Guizhou Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.