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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Surgical Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1387611
This article is part of the Research Topic Multimodal Treatment of Oligometastatic Esophagogastric Cancer: State of the Art and Future Perspectives View all 3 articles
Clinicopathologic Features and Surgical Treatment Prognosis of Esophageal Carcinosarcoma
Provisionally accepted- The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China
Carcinosarcoma is a rare esophageal tumor, accounting for approximately 0.27-2.8% of malignant esophageal tumors. Out of the 1261 patients who underwent surgical treatment for esophageal cancer, 16 cases were pathologically confirmed as carcinosarcoma. Among them, two underwent neoadjuvant chemotherapy, six received postoperative chemotherapy, one underwent exclusive radiotherapy postoperatively, and two received a combination of postoperative chemotherapy and radiotherapy. Carcinosarcomas predominantly occurred in the middle (43.75%) and lower (50%) segments of the esophagus. Microscopic examination revealed coexistence and transitional transitions between sarcomatous and carcinoma components. Among the 16 patients, 15 (93.75%) were positive for vimentin, 11 (68.75%) for CKpan, 13 (81.25%) for CK5/6, and 13 (81.25%) for p53. Pathological staging showed 5 cases in stage T1, 2 in stage T2, and 9 in stage T3, with lymph node metastasis observed in 6 cases (37.5%). TNM staging revealed 3 cases in stage I, 9 in stage II, and 4 in stage III. The overall 1, 3, and 5-year survival rates were 86.67%, 62.5%, and 57.14%, respectively. Univariate analysis indicated that pathological N staging influenced survival rates, while multivariate analysis demonstrated that pathological N staging was an independent prognostic factor. Complete surgical
Keywords: esophageal cancer, Carcinosarcoma, CLINICAL PATHOLOGY, surgical treatment, Prognosis analysis
Received: 18 Feb 2024; Accepted: 31 Jul 2024.
Copyright: © 2024 Shen, Lu, Liu, Chen, Chen, Wu, Wang, Ge, Han, Wang, Zhang, Yin, Jia, Zheng, Wang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fei Sun, The Affiliated Taizhou People's Hospital, Nanjing Medical University, Taizhou, China
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