AUTHOR=Ezenkwa Uchenna S. , Lawan Aliyu Ibrahim , Garbati Musa Abubakar , Suleiman Dauda E. , Katagum Dauda A. , Kabir Abba , Adamu Adamu Isa , Modu Abubakar Kolomi , Olanrewaju Olaniyi David , Dachi Rufai Abdu , Abdullahi Yusuf Mohammed , Alkali Muhammed , Bojude Danladi Adamu , Usman Hadiza Abdullahi , Omotoso Ayodele , Schlumbrecht Matthew , George Sophia H. L. , Audu Bala Mohammed TITLE=Emerging cancer disease burden in a rural sub-Saharan African population: northeast Nigeria in focus JOURNAL=Frontiers in Oncology VOLUME=14 YEAR=2024 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1380615 DOI=10.3389/fonc.2024.1380615 ISSN=2234-943X ABSTRACT=Introduction

Sub-Saharan Africa (SSA) is plagued by myriads of diseases, mostly infectious; but cancer disease burden is rising among non-communicable diseases. Nigeria has a high burden of cancer, however its remote underserved culturally-conserved populations have been understudied, a gap this study sought to fill.

Methods

This was a cross-sectional multi-institutional descriptive study of histologically diagnosed cancers over a four-year period (January 2019-December 2022) archived in the Departments of Pathology and Cancer Registries of six tertiary hospitals in the northeast of Nigeria. Data obtained included age at diagnosis, gender, tumor site and available cancer care infrastructure. Population data of the study region and its demographics was obtained from the National Population Commission and used to calculate incident rates for the population studied.

Results

A total of 4,681 incident cancer cases from 2,770 females and 1,911 males were identified. The median age at diagnosis for females was 45 years (range 1–95yrs), and 56 years (range 1–99yrs) for males. Observed age-specific incidence rates (ASR) increased steadily for both genders reaching peaks in the age group 80 years and above with the highest ASR seen among males (321/100,000 persons) compared to females (215.5/100,000 persons). Breast, cervical, prostatic, colorectal and skin cancers were the five most common incident cancers. In females, breast, cervical, skin, ovarian and colorectal cancers were the top five malignancies; while prostate, haematolymphoid, skin, colorectal and urinary bladder cancers predominated in men.

Conclusion

Remote SSA communities are witnessing rising cancer disease burden. Proactive control programs inclusive of advocacy, vaccination, screening, and improved diagnostics are needed.