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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1380195
This article is part of the Research Topic Peripheral Blood-Based Biomarkers for Immune Monitoring of Cancer and Cancer Therapy View all 16 articles

Predictive value of peri-chemotherapy hematological parameters for febrile neutropenia in cancer patients

Provisionally accepted
Hongyuan Jia Hongyuan Jia 1Long Liang Long Liang 1Xue Chen Xue Chen 2Wenzhong Zha Wenzhong Zha 3Wei Diao Wei Diao 4Wei Zhang Wei Zhang 4*
  • 1 Department of Radiation Therapy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute,Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China
  • 2 Sichuan Taikang Hospital, Chengdu, China
  • 3 Department of Biomedical informatics, Sichuan Cancer Center, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China
  • 4 Department of Nuclear Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China

The final, formatted version of the article will be published soon.

    Objective The study aimed to compare hematological parameters pre- and early post-chemotherapy, and evaluate their values for predicting febrile neutropenia (FN). Methods Patients diagnosed with malignant solid tumors receiving chemotherapy were included. Blood cell counts peri-chemotherapy and clinical information were retrieved from hospital information system. We used Lasso method for variable selection and fitted selected variables to a logistic model. We assessed the performance of the prediction model by the area under the ROC curve. Results The study population consisted of 4130 patients with common solid tumors receiving triple weeks chemotherapy regime in Sichuan Cancer Hospital from Feb 2019 to March 2022. In the FN group, change percentage of neutrophil count decreased less (-0.02, CI: -0.88 - 3.48 vs - 0.04, CI: -0.83 - 2.24). Among hematological parameters, lower post-chemotherapy lymphocyte count (OR 0.942, CI: 0.934 - 0.949), change percentage of platelet (OR 0.965, CI: 0.955 - 0.975) and higher change percentage of post-chemotherapy neutrophil count (OR 1.015, CI: 1.011 - 1.018), pre-chemotherapy NLR (OR 1.002, CI: 1.002 - 1.002) predicted an increased risk of FN. These factors improved the predicting model based on clinical factors alone. The AUC of combination model was 0.8275. Conclusions Peri-chemotherapy hematological markers improve the prediction of FN.

    Keywords: Febrile neutropenia, chemotherapy, hematological parameters, prediction, nomogram

    Received: 01 Feb 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Jia, Liang, Chen, Zha, Diao and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wei Zhang, Department of Nuclear Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China

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