AUTHOR=Salceda-Rivera Violeta , Tejocote-Romero Isidoro , Osorio Diana S. , Bellido-Magaña Rosalba , López-Facundo Araceli , Anaya-Aguirre Susana E. , Ortiz-Morales Daniel , Rivera-Luna Roberto , Reyes-Gutiérrez Evelyne , Rivera-Gómez Rebeca , Velasco-Hidalgo Liliana , Cortés-Alva Deyanira , Lagarda-Arrechea Sandra , Arreguín-González Farina E. , Benito-Reséndiz Alma E. , Chávez-Gallegos Silvia , Pérez-Rivera Eloy , Gaytán-Fernández Guillermo J. , León-Espitia José A. , Domínguez-Sánchez Jociela , Leal-Cavazos Carlos , Simón-González Citlalli , Larios-Farak Tania C. , Macías-García Nubia A. , García-Espinosa Ana C. , Guerrero-Maymes Francisco , Casillas-Toral Paola , González-Ramella Oscar TITLE=Impact of treatment and clinical characteristics on the survival of children with medulloblastoma in Mexico JOURNAL=Frontiers in Oncology VOLUME=14 YEAR=2024 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1376574 DOI=10.3389/fonc.2024.1376574 ISSN=2234-943X ABSTRACT=Introduction

Data on medulloblastoma outcomes and experiences in low- and middle-income countries, especially in Latin America, is limited. This study examines challenges in Mexico’s healthcare system, focusing on assessing outcomes for children with medulloblastoma in a tertiary care setting.

Methods

A retrospective analysis was conducted, involving 284 patients treated at 21 pediatric oncology centers in Mexico.

Results

High-risk patients exhibited markedly lower event-free survival than standard-risk patients (43.5% vs. 78.3%, p<0.001). Influential factors on survival included anaplastic subtype (HR 2.4, p=0.003), metastatic disease (HR 1.9, p=0.001); residual tumor >1.5cm², and lower radiotherapy doses significantly impacted event-free survival (EFS) and overall survival (OS). Platinum-based chemotherapy showed better results compared to the ICE protocol in terms of OS and EFS, which was associated with higher toxicity. Patients under 3 years old displayed notably lower OS and EFS compared to older children (36.1% vs. 55.9%, p=0.01).