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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Epidemiology and Prevention
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1374927
This article is part of the Research Topic The Future of Cancer Surveillance Research View all 22 articles

Causal Association of Peripheral Immune Cell Counts with Risk of Prostate Cancer: Insights from Bidirectional Mendelian Randomization

Provisionally accepted
Xiaolu Ren Xiaolu Ren 1,2,3Li Zhang Li Zhang 4*Kehua W. Ren Kehua W. Ren 5*Fang LI Fang LI 6*
  • 1 Other, Kubang Kerian, Malaysia
  • 2 Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Region, China
  • 3 School of Medical Sciences, Universiti Sains Malaysia (USM), Kota Bharu, Kelantan Darul Naim, Malaysia
  • 4 Department of Urology, Suzhou Wuzhong People’s Hospital, Wuzhong, China
  • 5 Department of Vascular Surgery, General Hospital of Ningxia Medical, Yinchuan, Henan Province, China
  • 6 Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, Henan Province, China

The final, formatted version of the article will be published soon.

    This study aimed to examine the causal relationships between peripheral immune cell counts and prostate cancer, adhering to Mendelian Randomization reporting guidelines for transparency and reproducibility.In this study, bidirectional Mendelian randomization (MR) analysis, which includes MR-Egger, weighted median, weighted mode, and inverse variance weighted (IVW) approaches, was utilized to evaluate the bidirectional causal relationship between peripheral immune cell counts and the risk of PCa.The primary analysis using the IVW method suggests a potential causal association between basophil counts and the risk of prostate cancer (PCa), with an odds ratio (OR) of 1.111 and a 95% confidence interval (CI) of 1.011-1.222 (P = 0.028). Conversely, non-causal associations have been observed between other peripheral immune cell types, such as white blood cells, neutrophils, lymphocytes, eosinophils, or monocytes, and the incidence of PCa (P values > 0.05). Furthermore, although reverse analysis indicated a causal link between PCa and the 2 counts of leukocytes and neutrophils (OR = 1.013; 95% CI = 1.002-1.225; P = 0.018 and OR = 1.013; 95% CI = 1.002-1.025; P = 0.019), no causal association was detected between PCa and basophil count (P value > 0.050).This study suggests a potential bidirectional link between peripheral immune cells and prostate cancer, but inconsistencies in Mendelian Randomization methods mean these findings are preliminary and require further investigation.

    Keywords: ：Causal, Peripheral immune cells, Prostate cancer risk, insights, bidirectional Mendelian randomization

    Received: 23 Jan 2024; Accepted: 15 Oct 2024.

    Copyright: © 2024 Ren, Zhang, Ren and LI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Li Zhang, Department of Urology, Suzhou Wuzhong People’s Hospital, Wuzhong, China
    Kehua W. Ren, Department of Vascular Surgery, General Hospital of Ningxia Medical, Yinchuan, Henan Province, China
    Fang LI, Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, Henan Province, China

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