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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Epidemiology and Prevention
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1365702
This article is part of the Research Topic Current Concepts in Epidemiology, Diagnosis, Associated Co-Morbidities, and Therapeutics of Non-Melanoma Skin Cancers: Beyond Basal Cell and Squamous Cell Carcinomas View all 10 articles

Advanced lung cancer inflammation index is associated with prognosis in skin cancer patients: a retrospective cohort study

Provisionally accepted
Weifeng Lan Weifeng Lan 1Wanly Zhuang Wanly Zhuang 2*Xuewen Wang Xuewen Wang 3*Zhou Lin Zhou Lin 1*Liqin Fu Liqin Fu 1*Yanping Zhang Yanping Zhang 1*Yuqing Wen Yuqing Wen 1*
  • 1 Department of Plastic Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China
  • 2 Department of Hepatobiliary Medicine,Dongfang Affiliated Hospital of Xiamen University, Fuzhou, Fujian Province, China
  • 3 Department of Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    Background: Skin cancer ranks as one of the most prevalent malignant tumors affecting humans. This study was designed to explore the correlation between the advanced lung cancer inflammation index (ALI), a metric that gauged both nutrition and inflammation statuses, in skin cancer patients and their subsequent prognosis.Methods: Data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2018 were scrutinized, along with mortality tracking extending to December 31, 2019. Kaplan-Meier survival curves and COX regression analysis, utilizing NHANES-recommended weights, delineated the association between ALI levels and skin cancer prognosis. To decipher the potential non-linear relationship, a restricted cubic spline analysis was applied. Additionally, stratified analysis was conducted to affirm the robustness of our findings.The 1,149 patients participating in NHANES 1999-2018 were enrolled. We observed a reverse J-shaped non-linear relationship between ALI and both skin cancer all-cause mortality and cancer mortality, with inflection points at 81.13 and 77.50, respectively.The ALI served as a comprehensive indicator of a patients nutrition and inflammation status and was demonstrably linked to the prognosis in skin cancer cases.The meticulous evaluation and continuous monitoring of these parameters in skin cancer patients bear clinical importance.

    Keywords: Skin Cancer, All-cause mortality, Cancer mortality, Advanced lung cancer inflammation index, NHANES

    Received: 08 Feb 2024; Accepted: 27 Sep 2024.

    Copyright: © 2024 Lan, Zhuang, Wang, Lin, Fu, Zhang and Wen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wanly Zhuang, Department of Hepatobiliary Medicine,Dongfang Affiliated Hospital of Xiamen University, Fuzhou, Fujian Province, China
    Xuewen Wang, Department of Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China
    Zhou Lin, Department of Plastic Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China
    Liqin Fu, Department of Plastic Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China
    Yanping Zhang, Department of Plastic Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China
    Yuqing Wen, Department of Plastic Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.