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CASE REPORT article

Front. Oncol.
Sec. Surgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1362024
This article is part of the Research Topic Characterization and Differential Diagnosis of Host Immunity in Patients with Bone Infections and Bone Tumors View all 4 articles

Primary osteosarcoma of the breast during lactation: a case report and literature review

Provisionally accepted
Huifang Zhuo Huifang Zhuo 1,2,3Yubei Duan Yubei Duan 1,2*Shuangshuang Dong Shuangshuang Dong 1,2,4*Jun Zhang Jun Zhang 1,2,3*Zijing Wang Zijing Wang 3,5*Lian Meng Lian Meng 1,2,3*Chenyan Wang Chenyan Wang 1,2*Man Li Man Li 1,2*Xiaotian Yang Xiaotian Yang 6*Ning Wang Ning Wang 1,2,3*Jian Ming Hu Jian Ming Hu 1,2
  • 1 Department of Pathology, School of Medicine, Shihezi University, Shihezi, Xinjiang Uyghur Region, China
  • 2 Department of Pathology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang Uyghur Region, China
  • 3 NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang Uyghur Region, China
  • 4 Northern Jiangsu People's Hospital, Yangzhou University, Yangzhou, Jiangsu Province, China
  • 5 First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang Uyghur Region, China
  • 6 People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang Uyghur Region, China

The final, formatted version of the article will be published soon.

    Primary osteosarcoma of the breast (POB) is an aggressive and exceedingly rare tumor, and cases with onset during lactation are extremely rare. The exact mechanism of POB development remains unclear. They may originate from totipotent mesenchymal cells in the breast stroma or may be the result of neoplastic transformation of prior breast lesions. Here, we present the case of a 40-year-old Chinese woman who was found with a palpable tumor measuring approximately 3 cm in diameter in her right breast while breastfeeding 4 months post-partum. The lactating woman was misdiagnosed with lactational mastitis during her initial visit to a community hospital.However, due to negative bacterial cultures and ineffective anti-infective treatment, later on the patient was taken to a more advanced hospital where a tissue biopsy was taken. The superior hospital considered that it might be a malignant tumor and performed local excision of the breast mass, leading to a final pathological diagnosis of POB. This is the first reported case of primary osteosarcoma during breastfeeding. We hope that this case report will improve readers' understanding of the diagnosis and differential diagnosis of POB, especially for patients with atypical clinical symptoms and imaging findings, which should not be taken lightly.

    Keywords: Breast malignancy, primary osteosarcoma of the breast, Lactation, Pathological diagnosis, case report

    Received: 27 Dec 2023; Accepted: 16 Oct 2024.

    Copyright: © 2024 Zhuo, Duan, Dong, Zhang, Wang, Meng, Wang, Li, Yang, Wang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yubei Duan, Department of Pathology, School of Medicine, Shihezi University, Shihezi, 832000, Xinjiang Uyghur Region, China
    Shuangshuang Dong, Department of Pathology, School of Medicine, Shihezi University, Shihezi, 832000, Xinjiang Uyghur Region, China
    Jun Zhang, Department of Pathology, School of Medicine, Shihezi University, Shihezi, 832000, Xinjiang Uyghur Region, China
    Zijing Wang, NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, 832003, Xinjiang Uyghur Region, China
    Lian Meng, Department of Pathology, School of Medicine, Shihezi University, Shihezi, 832000, Xinjiang Uyghur Region, China
    Chenyan Wang, Department of Pathology, School of Medicine, Shihezi University, Shihezi, 832000, Xinjiang Uyghur Region, China
    Man Li, Department of Pathology, School of Medicine, Shihezi University, Shihezi, 832000, Xinjiang Uyghur Region, China
    Xiaotian Yang, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, 830001, Xinjiang Uyghur Region, China
    Ning Wang, Department of Pathology, School of Medicine, Shihezi University, Shihezi, 832000, Xinjiang Uyghur Region, China

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