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CASE REPORT article

Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1361928

Germline CHEK2 Mutation is Associated with a Giant Cell Glioblastoma

Provisionally accepted
Yongfeng Bi Yongfeng Bi 1*Dong Wan Dong Wan 2Si Chen Si Chen 2*Huafei Chen Huafei Chen 2Lingchuan Guo Lingchuan Guo 3*Xiaoshun He Xiaoshun He 3*Rong Rong Rong Rong 4Wei Gao Wei Gao 5*Sheng Xiao Sheng Xiao 6*
  • 1 Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
  • 2 Suzhou Sano Precision Medicine Ltd, Suzhou 215000, China, Suzhou, China
  • 3 Department of Pathology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
  • 4 Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu Province, China
  • 5 Department of Neurosurgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
  • 6 Deaprtment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

The final, formatted version of the article will be published soon.

    Ethics approval statement： This study was approved by the institutional review board at respective institutions.Patient consent statement: this study was consent by the patient.Contributions: Yongfeng Bi and Wei Gao contributed to patient care and clinical data analysis. Dong Wan, Si Chen, Huafei Chen, Rong Rong and 2 Jinyuan Xiao performed laboratory work and result analysis. Lingchuan Guo and Xiaoshun He provided expertise in histopathologic diagnosis. Wei Gao and Sheng Xiao supervised the project and contributed to paper writing. All authors have reviewed and approved the final manuscript.

    Keywords: CHEK2, Glioblastoma, Haploidy, Met, germline

    Received: 27 Dec 2023; Accepted: 02 Sep 2024.

    Copyright: © 2024 Bi, Wan, Chen, Chen, Guo, He, Rong, Gao and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yongfeng Bi, Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu Province, China
    Si Chen, Suzhou Sano Precision Medicine Ltd, Suzhou 215000, China, Suzhou, China
    Lingchuan Guo, Department of Pathology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
    Xiaoshun He, Department of Pathology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
    Wei Gao, Department of Neurosurgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
    Sheng Xiao, Deaprtment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.