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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1359017

The impact of tumor burden score on prognosis in patients after radical resection of hepatocellular carcinoma: A singlecenter retrospective study

Provisionally accepted
Junzhang Huang Junzhang Huang Wei Suosu Wei Suosu Yuntian Tang Yuntian Tang Qiuhuan Zhang Qiuhuan Zhang Yi Tang Yi Tang Wei Huang Wei Huang Ying Zhou Ying Zhou Chongde Mo Chongde Mo Xiaofeng Dong Xiaofeng Dong *Jianrong Yang Jianrong Yang *
  • People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Region, China

The final, formatted version of the article will be published soon.

    This study examines the relationship between tumor burden score (TBS) and survival and recurrence following radical resection of hepatocellular carcinoma through a cohort study conducted in the Guangxi population of China.Methods: This cohort study eventually recruited 576 HCC patients undergoing radical resection of HCC in the People's Hospital of Guangxi Zhuang Autonomous Region during 2013-2022. After determining the best threshold TBS, all cases were grouped to evaluate the relationship between TBS versus overall survival (OS) and cumulative recurrence. Using X-Tile software, the best threshold TBS to judge patient prognostic outcome following radical resection of HCC was 10.77.Results: Kaplan-Meier curve analysis revealed that patients with high TBS showed considerably decreased OS relative to the control group, accompanied by an increased recurrence rate. According to multivariate Cox proportional regression, the patients with high TBS were associated with poorer OS (HR = 2.56, 95% CI 1.64-3.99, P < 0.001) and recurrence-free survival (RFS) (HR = 1.55, 95% CI 1.02-2.35, P < 0.001).In patients undergoing radical resection for HCC, higher TBS was significantly related to shorter OS and RFS.

    Keywords: Tumor Burden, Hepatocellular Carcinoma, Radical resection, Survival, Recurrence

    Received: 20 Dec 2023; Accepted: 09 Oct 2024.

    Copyright: © 2024 Huang, Suosu, Tang, Zhang, Tang, Huang, Zhou, Mo, Dong and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaofeng Dong, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Region, China
    Jianrong Yang, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Region, China

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