AUTHOR=Carrolo Margarida , Miranda João A. I. , Vilhais Guilherme , Quintela António , Sousa Mário Fontes e , Costa Diogo Alpuim , Pinto Francisco R. 

TITLE=Metastatic organotropism: a brief overview

JOURNAL=Frontiers in Oncology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1358786

DOI=10.3389/fonc.2024.1358786

ISSN=2234-943X

ABSTRACT=<p>Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.</p>