Skip to main content

ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cancer Epidemiology and Prevention
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1354235

Serum Uric Acid and Prostate Cancer: Findings from the NHANES (2007-2020)

Provisionally accepted
Yu Yan Yu Yan 1*Hong Lin Hong Lin 2Zhi-Yao He Zhi-Yao He 2Ling Wang Ling Wang 1
  • 1 West China School of Pharmacy, Sichuan University, Chengdu, China
  • 2 West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    The relationship between serum uric acid (SUA) levels and prostate cancer (PCa) remains controversial. This cross-sectional study investigated the association between SUA levels and PCa incidence.: A total of 9,776 participants aged ≥40 from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2020 were included, 503 of whom had PCa. Weighted univariate logistic regression, multivariate logistic regression, and smooth-fitting curve analyses were used to analyze the association between SUA and PCa incidence. Concurrently, the fitted smoothing curves were used to explore the potential nonlinear relationships. If nonlinearity was observed, a recursive algorithm further calculated the inflection point.Results: Three models were used to analyze the correlation between SUA levels and PCa incidence. All regression models demonstrated a negative correlation between SUA levels and PCa incidence (Model 1: OR = 0.88, 95% CI=0.80-0.97; Model 2: OR = 0.87, 95% CI=0.80-0.96; Model 3: OR = 0.87, 95% CI=0.78-0.96). According to the trend test, with increasing SUA, the risk of PCa showed a downward trend (three models p for trend = 0.037, 0.015, 0.016). According to the subgroup analysis, a significant negative correlation between SUA and PCa was detected in individuals aged >60 years, non-Hispanic whites, those of other races, and those with hypertension. Moreover, the association between SUA and PCa followed a U-shaped curve among participants without hypertension, and the inflection point of SUA was 5.1 mg/dl.This cross-sectional study revealed a negative relationship between SUA levels and the risk of PCa, particularly in specific demographic groups. These findings offer a fresh perspective on the role of SUA in PCa patients, potentially paving the way for new approaches for the prevention and treatment of PCa.However, further studies are necessary to validate these findings.

    Keywords: AST: Aminotransferase, BUN: Blood Urea Nitrogen, SCR: serum creatinine, TBil: Total Bilirubin, TC::total cholesterol, TG: Triglyceride, BMI: body mass index, HBP: high blood pressure, DM: Diabetes Mellitus

    Received: 20 Jan 2024; Accepted: 06 Sep 2024.

    Copyright: © 2024 Yan, Lin, He and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yu Yan, West China School of Pharmacy, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.