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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1353067

Administration Sequences in Single-Day Chemotherapy Regimens for Breast Cancer: A Comprehensive Review from a Practical Perspective

Provisionally accepted
Miaohui WU Miaohui WU 1,2Xiaoyan Huang Xiaoyan Huang 3*Meijun Chen Meijun Chen 4*Yin Zhang Yin Zhang 1*
  • 1 Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China
  • 2 School of Pharmacy, Fujian Medical University, Fuzhou, China
  • 3 Department of Endocrinology, Quanzhou First Hospital, Fujian Medical University, Quanzhou, China
  • 4 Department of Pharmacy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China

The final, formatted version of the article will be published soon.

    Chemotherapy, as the most common modality in anti-tumor therapy, often neglects the sequence of drug administration within a single day. This article delves into the impact of the order of drug administration in combination chemotherapy protocols for breast cancer on both efficacy and toxicity. We conducted an in-depth exploration and analysis based on current evidence from evidence-based medicine, encompassing aspects of cell proliferation kinetics, drug interactions, chronopharmacology, and principles of drug irritability. Furthermore, we systematically classifies and analyzes commonly used combination drug regimens, and provides graded recommendations and a reasoned analysis, offering a valuable reference for clinical decision-making.

    Keywords: breast cancer, chemotherapy, sequence, single-day, review

    Received: 13 Dec 2023; Accepted: 04 Sep 2024.

    Copyright: © 2024 WU, Huang, Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaoyan Huang, Department of Endocrinology, Quanzhou First Hospital, Fujian Medical University, Quanzhou, China
    Meijun Chen, Department of Pharmacy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China
    Yin Zhang, Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, Fujian Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.