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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1341056

Identification of lncRNA dual targeting PD-L1 and PD-L2 as a novel prognostic predictor for gastric cancer

Provisionally accepted
Lina Zhang Lina Zhang 1Jiongyu Chen Jiongyu Chen 2Yuxin Liu Yuxin Liu 1Yue Zhang Yue Zhang 1Liangli Hong Liangli Hong 1Xinxin Li Xinxin Li 1Shuhui Liu Shuhui Liu 3Lin Peng Lin Peng 2*Yiteng Huang Yiteng Huang 1*
  • 1 First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China
  • 2 Cancer Hospital, College of Medicine, Shantou University, Shantou, Guangdong Province, China
  • 3 Department of Pathology, College of Medicine, Shantou University, Shantou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Background: Although breakthroughs have been achieved in gastric cancer (GC) therapy with immune checkpoint inhibitors (ICIs) targeting programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1), the acquisition of high response rate network was proposed in macrophages. Using the exoRBase database, LINC01094 was assumed in blood exosomes of GC patients The results of knockdown experiments and luciferase reporter assays revealed that LINC01094 interacted with miR-17-5p and served as a miRNA sponge to regulate the expression of PD-L1 and PD-L2.Conclusion: LINC01094 dually regulates the expression of PD-L1 and PD-L2 and shapes the immunosuppressive tumor microenvironment via sponging miR-17-5p.LINC01094 may serve as a potential prognostic predictor and therapeutic target in GC.

    Keywords: Gastric Carcinoma, LINC01094, PD-L1, PD-L2, Tumor immune microenvironment

    Received: 19 Nov 2023; Accepted: 20 Sep 2024.

    Copyright: © 2024 Zhang, Chen, Liu, Zhang, Hong, Li, Liu, Peng and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lin Peng, Cancer Hospital, College of Medicine, Shantou University, Shantou, Guangdong Province, China
    Yiteng Huang, First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong Province, China

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