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CASE REPORT article

Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1339582

Case Report: A rare case of malignant solitary fibrous tumor in an adult with an epithelioid pattern in the occipital region

Provisionally accepted
Ke Huang Ke Huang Wen-Wen Liu Wen-Wen Liu Xiuwen Chen Xiuwen Chen Yin-Hua Hao Yin-Hua Hao Sen-Yuan Luo Sen-Yuan Luo Ling-Ling Yuan Ling-Ling Yuan Yu-gang Huang Yu-gang Huang *Xian-bin Tang Xian-bin Tang
  • Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China

The final, formatted version of the article will be published soon.

    We illustrated a rare case of malignant solitary fibrous tumor (MSFT) with epithelioid morphology in the occipital region of a 59-year-old female, in which a rare NAB2ex7-STAT6 exon15/16 double fusion subtype was detected by the Next-generation sequencing (NGS) and STAT6 immunohistochemistry (IHC) was diffusely and strongly positively expressed, without recurrence after 20 months of postoperative follow-up. The morphological and molecular genetic aspects and the differential diagnosis are described, and the relevant literature was assessed in order to broaden our understanding and diagnostic capability of this malignancy.

    Keywords: case report, Malignant solitary fibrous tumor, NAB2-STAT6 fusion, Diagnostic pathology, Next-generation sequencing-NGS

    Received: 16 Nov 2023; Accepted: 01 Aug 2024.

    Copyright: © 2024 Huang, Liu, Chen, Hao, Luo, Yuan, Huang and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yu-gang Huang, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China

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