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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Radiation Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1326355

Long-term outcomes of LDR-Brachytherapy for Localized Prostate Cancer

Provisionally accepted
Lauri Mäkelä Lauri Mäkelä 1,2*Anssi Pétas Anssi Pétas 2Arto Mikkola Arto Mikkola 2Harri Visapää Harri Visapää 2
  • 1 University of Helsinki, Helsinki, Finland
  • 2 Helsinki University Central Hospital, Helsinki, Uusimaa, Finland

The final, formatted version of the article will be published soon.

    This retrospective study aims to evaluate the long-term efficacy and urinary toxicity of LDRbrachytherapy for localized prostate cancer.235 primary prostate cancer patients treated with LDR-brachytherapy and subsequently followed up in our center were included in this study. Biochemical relapse free survival (bRFS), overall survival (OS), and cancer-specific survival (CSS) were evaluated.Additionally, the incidence of late urinary complications was recorded.Median follow-up time was 11,6 years. 181 patients (77%) were classified as low-risk patients, while 52 patients (22,1%) were intermediate risk. The overall bRFS was 83,8% at 5 years and 72,4% at 10 years. 5-and 10-year OS were 97,8% and 87,8% respectively. There was no statistically significant difference in bRFS or OS between different risk groups. The rate of late urinary complications was 8,9%. Volume of prostate had a statistically significant effect on bRFS, as smaller prostate volumes led to worse bRFS.This retrospective study shows that LDR brachytherapy is an effective treatment for low-and intermediate risk prostate cancer patients with relatively low but still significant risk of late urinary complications.

    Keywords: prostate cancer, LDR, Brachytherapy, Radiotherapy, long term ouctomes

    Received: 23 Oct 2023; Accepted: 26 Dec 2024.

    Copyright: © 2024 Mäkelä, Pétas, Mikkola and Visapää. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lauri Mäkelä, University of Helsinki, Helsinki, Finland

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