AUTHOR=Zhang Tianyu , Lin Zhili , Zheng Ziwei , Wang Quanqiang , Zhou Shujuan , Zhang Bingxin , Zheng Dong , Chen Zixing , Zheng Sisi , Zhang Yu , Lin Xuanru , Dong Rujiao , Chen Jingjing , Qian Honglan , Hu Xudong , Zhuang Yan , Zhang Qianying , Jin Zhouxiang , Jiang Songfu , Ma Yongyong 

TITLE=Prognostic significance of β2-microglobulin decline index in multiple myeloma

JOURNAL=Frontiers in Oncology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1322680

DOI=10.3389/fonc.2024.1322680

ISSN=2234-943X

ABSTRACT=<sec><title>Purpose</title><p>To assess the prognostic significance of β2-microglobulin decline index (β2M DI) in multiple myeloma (MM).</p></sec><sec><title>Methods</title><p>150 MM patients diagnosed with MM were enrolled in this study. Cox proportional hazards model was used to analyze the uni- and multivariate prognosis in training cohort (n=105). A new combined prognostic model containing β2M DI was built up based on the data in training cohort. The validation group was used to verify the model.</p></sec><sec><title>Results</title><p>β2M DI showed significant correlation with prognosis in both uni- and multivariate analyses and had a good correlation with complete response (CR) rate and deep remission rate. The ROC and calibration curves in validation cohort (n=45) indicated a good predictive performance of the new model. Based on the median risk score of the training group, we classified patients into high- and low- risk groups. In both training and validation groups, patients in the low-risk group had longer overall survival (OS) time than that in the high-risk group (p&lt;0.05).</p></sec><sec><title>Conclusion</title><p>β2M DI is a good predictive index for predicting treatment response and survival time in MM patients. The prognostic model added with β2M DI showed a better correlation with OS.</p></sec>