AUTHOR=Peng Li , Chen Bijuan , Yu Erhan , Lin Yifei , Lin Jiahao , Zheng Dechun , Fu Yu , Chen Zhipeng , Zheng Hanchen , Zhan Zhouwei , Chen Yunbin 

TITLE=The application value of LAVA-flex sequences in enhanced MRI scans of nasopharyngeal carcinoma: comparison with T1WI-IDEAL

JOURNAL=Frontiers in Oncology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1320280

DOI=10.3389/fonc.2024.1320280

ISSN=2234-943X

ABSTRACT=<sec><title>Introduction</title><p>Magnetic resonance imaging (MRI) staging scans are critical for the diagnosis and treatment of patients with nasopharyngeal cancer (NPC). We aimed to evaluate the application value of LAVA-Flex and T1WI-IDEAL sequences in MRI staging scans.</p></sec><sec><title>Methods</title><p>Eighty-four newly diagnosed NPC patients underwent both LAVA-Flex and T1WI-IDEAL sequences during MRI examinations. Two radiologists independently scored the acquisitions of image quality, fat suppression quality, artifacts, vascular and nerve display. The obtained scores were compared using the Wilcoxon signed rank test. According to the signal intensity (SI) measurements, the uniformity of fat suppression, contrast between tumor lesions and subcutaneous fat tissue, and signal-to-noise ratio (SNR) were compared by the paired t-test.</p></sec><sec><title>Results</title><p>Compared to the T1WI-IDEAL sequence, LAVA-Flex exhibited fewer artifacts (<italic>P</italic>&lt;0.05), better visualization of nerves and vessels (<italic>P</italic>&lt;0.05), and performed superior in the fat contrast ratio of the primary lesion and metastatic lymph nodes (0.80 <italic>vs</italic>. 0.52, 0.81 <italic>vs</italic>. 0.56, separately, <italic>P</italic>&lt;0.001). There was no statistically significant difference in overall image quality, tumor signal-to-noise ratio (SNR), muscle SNR, and the detection rate of lesions between the two sequences (<italic>P</italic>&gt;0.05). T1WI-IDEAL was superior to LAVA-Flex in the evaluation of fat suppression uniformity (<italic>P</italic>&lt;0.05).</p></sec><sec><title>Discussion</title><p>LAVA-Flex sequence provides satisfactory image quality and better visualization of nerves and vessels for NPC with shorter scanning times.</p></sec>