AUTHOR=Sukmana Bayu Indra , Saleh Raed Obaid , Najim Maryam Abdulrahman , AL-Ghamdi Hasan S. , Achmad Harun , Al-Hamdani Mais Mazin , Taher Abbas AY. , Alsalamy Ali , Khaledi Mansoor , Javadi Kasra 

TITLE=Oral microbiota and oral squamous cell carcinoma: a review of their relation and carcinogenic mechanisms

JOURNAL=Frontiers in Oncology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1319777

DOI=10.3389/fonc.2024.1319777

ISSN=2234-943X

ABSTRACT=<p>Oral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer worldwide. Emerging research suggests a strong association between OSCC and the oral microbiota, a diverse community of bacteria, fungi, viruses, and archaea. Pathogenic bacteria, in particular <italic>Porphyromonas gingivalis</italic> and <italic>Fusobacterium nucleatum</italic>, have been closely linked to OSCC. Moreover, certain oral fungi, such as <italic>Candida albicans</italic>, and viruses, like the human papillomavirus, have also been implicated in OSCC. Despite these findings, the precise mechanisms through which the oral microbiota influences OSCC development remain unclear and necessitate further research. This paper provides a comprehensive overview of the oral microbiota and its relationship with OSCC and discusses potential carcinogenic pathways that the oral microbiota may activate or modulate are also discussed.</p>