AUTHOR=Núñez-Enríquez Juan Carlos , Romo-Rodríguez Rubí , Gaspar-Mendoza Pedro , Zamora-Herrera Gabriela , Torres-Pineda Lizeth , Amador-Cardoso Jiovanni , López-Blanco Jebea A. , Alfaro-Hernández Laura , López-García Lucero , Rosas-Cruz Arely , Alberto-Aguilar Dulce Rosario , Trejo-Pichardo César Omar , Ramírez-Ramírez Dalia , Cruz-Maza Astin , Flores-Lujano Janet , Luna-Silva Nuria , Martínez-Martell Angélica , Martínez-Jose Karina , Ramírez-Ramírez Anabel , Solis-Poblano Juan Carlos , Zagoya-Martínez Patricia , Terán-Cerqueda Vanessa , Huerta-Moreno Andrea , Montiel-Jarquín Álvaro , Garrido-Hernández Miguel , Hernández-Ramos Raquel , Olvera-Caraza Daniela , Cruz-Medina Cynthia Shanat , Alvarez-Rodríguez Enoch , Chávez-Aguilar Lénica Anahí , Herrera-Olivares Wilfrido , García-Hidalgo Brianda , Cano-Cuapio Lena Sarahí , Guevara-Espejel Claudia , Juárez-Avendaño Gerardo , Balandrán Juan Carlos , Baños-Lara Ma. del Rocío , Cárdenas-González Mariana , Álvarez-Buylla Elena R. , Pérez-Tapia Sonia Mayra , Casique-Aguirre Diana , Pelayo Rosana TITLE=Implementation of a roadmap for the comprehensive diagnosis, follow-up, and research of childhood leukemias in vulnerable regions of Mexico: results from the PRONAII Strategy JOURNAL=Frontiers in Oncology VOLUME=14 YEAR=2024 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1304690 DOI=10.3389/fonc.2024.1304690 ISSN=2234-943X ABSTRACT=

The main objective of the National Project for Research and Incidence of Childhood Leukemias is to reduce early mortality rates for these neoplasms in the vulnerable regions of Mexico. This project was conducted in the states of Oaxaca, Puebla, and Tlaxcala. A key strategy of the project is the implementation of an effective roadmap to ensure that leukemia patients are the target of maximum benefit of interdisciplinary collaboration between researchers, clinicians, surveyors, and laboratories. This strategy guarantees the comprehensive management of diagnosis and follow-up samples of pediatric patients with leukemia, centralizing, managing, and analyzing the information collected. Additionally, it allows for a precise diagnosis and monitoring of the disease through immunophenotype and measurable residual disease (MRD) studies, enhancing research and supporting informed clinical decisions for the first time in these regions through a population-based study. This initiative has significantly improved the diagnostic capacity of leukemia in girls, boys, and adolescents in the regions of Oaxaca, Puebla, and Tlaxcala, providing comprehensive, high-quality care with full coverage in the region. Likewise, it has strengthened collaboration between health institutions, researchers, and professionals in the sector, which contributes to reducing the impact of the disease on the community.