AUTHOR=Wu Maoyuan , Zhang Wenwen , He Lianli , Zhu Ye , Jiang Xiaoling , Zhang Lixia , Yuan Xiwei , Li Tingchao 

TITLE=High-grade serous papillary ovarian carcinoma combined with nonkeratinizing squamous cell carcinoma of the cervix: a case report

JOURNAL=Frontiers in Oncology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1298109

DOI=10.3389/fonc.2024.1298109

ISSN=2234-943X

ABSTRACT=<p>Multiple primary malignant neoplasms are a rare gynecologic malignancy; particularly, cases originating from the heterologous organs, such as the ovary and cervix. Here, we report a case of two primary malignant neoplasms in a patient who had undergone laparoscopic radical hysterectomy + bilateral salpingo-oophorectomy + pelvic lymph node dissection + para-aortic lymphadenectomy + appendectomy + omentectomy + metastasectomy under general anesthesia. The patient experienced complete remission after six courses of postoperative chemotherapy with a standard Taxol and Carboplatin regimen. Genetic testing was performed to detect <italic>BRCA2</italic> mutations, and poly (ADP-ribose) polymerase (PARP) inhibitors were used for maintenance therapy.</p>