AUTHOR=Scarini João Figueira , Gonçalves Moisés Willian Aparecido , de Lima-Souza Reydson Alcides , Lavareze Luccas , de Carvalho Kimura Talita , Yang Ching-Chu , Altemani Albina , Mariano Fernanda Viviane , Soares Heloisa Prado , Fillmore Gary Chris , Egal Erika Said Abu 

TITLE=Potential role of the Eph/ephrin system in colorectal cancer: emerging druggable molecular targets

JOURNAL=Frontiers in Oncology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1275330

DOI=10.3389/fonc.2024.1275330

ISSN=2234-943X

ABSTRACT=<p>The Eph/ephrin system regulates many developmental processes and adult tissue homeostasis. In colorectal cancer (CRC), it is involved in different processes including tumorigenesis, tumor angiogenesis, metastasis development, and cancer stem cell regeneration. However, conflicting data regarding Eph receptors in CRC, especially in its putative role as an oncogene or a suppressor gene, make the precise role of Eph-ephrin interaction confusing in CRC development. In this review, we provide an overview of the literature and highlight evidence that collaborates with these ambiguous roles of the Eph/ephrin system in CRC, as well as the molecular findings that represent promising therapeutic targets.</p>