Skip to main content

CLINICAL TRIAL article

Front. Oncol.
Sec. Head and Neck Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1220640

Retrospective study of cisplatin plus radiotherapy toxicities in locally advanced squamous cell carcinoma of the head and neck -ReCisTT Study

Provisionally accepted
Ana Varges Gomes Ana Varges Gomes 1*Gilberto De Castro Jr Gilberto De Castro Jr 2Thiago B. de Oliveira Thiago B. de Oliveira 3Ana M. Colmenero Ana M. Colmenero 4Leonor Ribeiro Leonor Ribeiro 5Amanda Psyrri Amanda Psyrri 6,7Nicolas Magné Nicolas Magné 8,9Maria Plana Maria Plana 10Joana Marinho Joana Marinho 11,12Raul Giglio Raul Giglio 13Leticia I. Rey Leticia I. Rey 14Martin Angel Martin Angel 15Ana M. Macedo Ana M. Macedo 16,17
  • 1 Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • 2 Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil
  • 3 International Center for Research, AC Camargo Cancer Center, São Paulo, São Paulo, Brazil
  • 4 Centro Oncológico de Galicia, A Coruña, Spain
  • 5 Departamento de Medicina, Hospital de Santa Maria, Centro Hospitalar de Lisboa Norte, Lisbon, Portugal
  • 6 University General Hospital Attikon, Athens, Greece
  • 7 National and Kapodistrian University of Athens, Athens, Greece
  • 8 Institut de Cancérologie Lucien Neuwirth, Saint Priest en Jarez, France
  • 9 Department of Radiation Oncology, Institut Bergonié, Bordeaux, France
  • 10 Catalan Institute of Oncology, Barcelona, Spain
  • 11 Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia, Portugal
  • 12 Association for Research on Supportive Care in Oncology, Vila Nova de Gaia, Portugal
  • 13 Instituto de Oncología Ángel H. Roffo, Buenos Aires, Buenos Aires, Argentina
  • 14 Complejo Hospitalario de Ourense, Ourense, Spain
  • 15 Instituto Alexander Fleming, Buenos Aires, Argentina
  • 16 Faculty of Medicine and Biomedical Sciences, University of Algarve, Faro, Portugal
  • 17 Evidenze - Knowledge in Health (Portugal), Lisbon, Portugal

The final, formatted version of the article will be published soon.

    Squamous cell carcinoma of the head and neck (SCCHN) is a multifactorial disease involving genetic and environmental factors representing one of the most frequent cancer-related deaths worldwide. Tobacco and alcohol use account for most SCCHN, while a growing subset of oropharyngeal cancers is causally associated with human papillomavirus (HPV) infection. Despite improvements in overall survival, patients with HPV-negative locally advanced (LA) SCCHN continue to have a poor prognosis. For these patients, the standard of care is radiotherapy with concurrent chemotherapy (RCT). This retrospective, multicenter, and observational study analyzed the treatment compliance of 326 patients with LA-SCCHN who underwent RCT between January 1st, 2014, and June 30th, 2017. This study also evaluated the potential factors associated with treatment compliance, the compliance impact on clinical response, and the main toxicities experienced by patients. A total of 274 (84%) patients were compliant and received the planned dose of cisplatin. Overall, 957 adverse events were reported in 98.2% of patients during the study. The overall response rate was 80.2%, with 60.4% of patients achieving a complete response. Despite the high treatment compliance, 62.6% of adverse events reported were related to cisplatin. Identifying risk factors associated with non-compliance could enable physicians to identify ineligible patients for cisplatin-based RCT and prevent patients from receiving inadequate treatment leading to severe adverse events.

    Keywords: SCCHN, Concurrent chemotherapy, Cisplatin, Compliance, Radiotherapy

    Received: 16 May 2023; Accepted: 13 Sep 2024.

    Copyright: © 2024 Varges Gomes, De Castro Jr, de Oliveira, Colmenero, Ribeiro, Psyrri, Magné, Plana, Marinho, Giglio, Rey, Angel and Macedo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ana Varges Gomes, Centro Hospitalar Universitário do Algarve, Faro, Portugal

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.