AUTHOR=Cervi Catherine , Sápi Zoltán , Bedics Gábor , Zajta Erik , Hegyi Lajos , Pápay Judit , Dezső Katalin , Varga Edit , Mudra Katalin , Bödör Csaba , Csóka Monika TITLE=Case report: Complete and durable response to larotrectinib (TRK inhibitor) in an infant diagnosed with angiosarcoma harbouring a KHDRBS1-NTRK3 fusion gene JOURNAL=Frontiers in Oncology VOLUME=Volume 13 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.999810 DOI=10.3389/fonc.2023.999810 ISSN=2234-943X ABSTRACT=
Significant improvements in the survival rates of paediatric cancer have been achieved over the past decade owing to recent advances in therapeutic and diagnostic strategies. However, disease progression and relapse remain a major challenge for the clinical management of paediatric angiosarcoma. Comprehensive genomic profiling of these rare tumours using high-throughput sequencing technologies may improve patient stratification and identify actionable biomarkers for therapeutic intervention. Here, we describe the clinical, histopathological, immunohistochemical and molecular profile of a novel and precision medicine-informed case where a